Literature DB >> 667696

The structure and maturation of intermediates in bacteriophage T7 DNA replication.

L Langman, V Paetkau, D Scraba, R C Miller, G S Roeder, P D Sadowski.   

Abstract

Concatemeric DNA from T7-infected cells consists of phage genomes in a linear head-to-tail arrangement. Adjacent genomes within a concatemer overlap for the length of the terminal repetition. Fast-sedimenting T7 DNA contains single-stranded regions at roughly unit-lentth intervals but these interruptions are heterogeneously distributed and do not occur at the genetic termini. Mutations in either bacteriophage genes 9, 18, or 19 (required for DNA maturation and packaging) lead to the synthesis and persistence of DNA with fewer interruptions than normal.

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Year:  1978        PMID： 667696     DOI： 10.1139/o78-078

Source DB:  PubMed          Journal:  Can J Biochem        ISSN： 0008-4018


  8 in total

1.  Multidimensional analysis of intracellular bacteriophage T7 DNA: effects of amber mutations in genes 3 and 19.

Authors:  P Serwer; R H Watson; S J Hayes
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

2.  Marker rescue and partial replication of bacteriophage T7 DNA.

Authors:  K B Burck; R C Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

3.  Length determination of the terminal redundant regions in the DNA of phage T7.

Authors:  B Dreiseikelmann; U Steger; W Wackernagel
Journal:  Mol Gen Genet       Date:  1980-04

4.  Impact of 2-bromo-5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole riboside and inhibitors of DNA, RNA, and protein synthesis on human cytomegalovirus genome maturation.

Authors:  Michael A McVoy; Daniel E Nixon
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

5.  Gene 2 protein of bacteriophage T7: purification and requirement for packaging of T7 DNA in vitro.

Authors:  J E LeClerc; C C Richardson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

6.  Change in priming sites for discontinuous DNA synthesis between the monomeric and concatemeric stages of phage T7 replication.

Authors:  K Sugimoto; T Miyasaka; A Fujiyama; Y Kohara; T Okazaki
Journal:  Mol Gen Genet       Date:  1988-03

7.  Genetic recombination of bacteriophage T7 in vivo studied by use of a simple physical assay.

Authors:  D Lee; P D Sadowski
Journal:  J Virol       Date:  1981-12       Impact factor: 5.103

8.  Characterization of the defects in bacteriophage T7 DNA synthesis during growth in the Escherichia coli mutant tsnB.

Authors:  M A DeWyngaert; D C Hinkle
Journal:  J Virol       Date:  1980-02       Impact factor: 5.103
  8 in total

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