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Literature DB >> 6668552

Sampling strategies for noncompartmental estimation of mean residence time.

Abstract

An optimization procedure is presented for selecting sample times for estimating mean residence time using noncompartmental data analysis. Performance of this experimental design strategy is evaluated using Monte Carlo simulations of a model for digoxin kinetics. The contribution of measurement error to the overall expected error in MRT estimates is examined and its importance emphasized. Also, the sensitivity of the proposed experimental design strategy to required assumptions is investigated using the digoxin model, and the importance of accurate estimates of extrapolated areas is noted.

Entities: Chemical

Mesh：

Substances：

Year: 1983 PMID： 6668552 DOI： 10.1007/bf01058960

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

6 in total

1. Theory of the mean absorption time, an adjunct to conventional bioavailability studies.

Authors: D J Cutler
Journal: J Pharm Pharmacol Date: 1978-08 Impact factor: 3.765

2. Bioavailability assessment: methods to estimate total area (AUC O to infinity) and total amount excreted (A infinity e) and importance of blood and urine sampling scheme with application to digoxin.

Authors: J G Wagner; J W Ayres
Journal: J Pharmacokinet Biopharm Date: 1977-10

5 in total

1. Bias and variance of extrapolated tails for area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC).

Authors: R D Purves
Journal: J Pharmacokinet Biopharm Date: 1992-10

2. Optimum numerical integration methods for estimation of area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC).

Authors: R D Purves
Journal: J Pharmacokinet Biopharm Date: 1992-06

3. The relevance of residence time theory to pharmacokinetics.

Authors: M Weiss
Journal: Eur J Clin Pharmacol Date: 1992 Impact factor: 2.953

Review 4. Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).

Authors: P Veng-Pedersen
Journal: Clin Pharmacokinet Date: 1989-12 Impact factor: 6.447

5. Accuracy of noncompartmental pharmacokinetic parameters estimated from bolus injection and steady-state infusion data.

Authors: M Looby; M Weiss
Journal: J Pharmacokinet Biopharm Date: 1995-12

5 in total

Sampling strategies for noncompartmental estimation of mean residence time.

1. Theory of the mean absorption time, an adjunct to conventional bioavailability studies.

2. Bioavailability assessment: methods to estimate total area (AUC O to infinity) and total amount excreted (A infinity e) and importance of blood and urine sampling scheme with application to digoxin.

3. Experimental design for estimating integrals by numerical quadrature, with applications to pharmacokinetic studies.

4. Statistical moments in pharmacokinetics.

5. The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.

6. A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximation.

1. Bias and variance of extrapolated tails for area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC).

2. Optimum numerical integration methods for estimation of area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC).

3. The relevance of residence time theory to pharmacokinetics.

Review 4. Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).

5. Accuracy of noncompartmental pharmacokinetic parameters estimated from bolus injection and steady-state infusion data.