| Literature DB >> 21188042 |
A C Ezike1, P A Akah, C O Okoli, S Udegbunam, N Okwume, C Okeke, O Iloani.
Abstract
The effects of the methanol extract of the stem bark of Prosopis africana (Guill., Perrott. and Rich.) Taubert (Fabaceae) on bleeding/clotting and coagulation time, excision and dead space wounds were studied in rats. Also, the extract was subjected to antibacterial, and acute toxicity and lethality (LD(50)) tests. The extract significantly (P<0.05) reduced bleeding/clotting and coagulation time in rats. It also reduced epithelialization period of excision wounds in rats and inhibited the growth of laboratory strains of Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella pneumoniae to varying extents. Acute toxicity and lethality (LD(50)) test on the extract established an LD(50) of 774 mg/kg (i.p) in mice while phytochemical analysis gave positive reactions for alkaloids, saponins, tannins, flavonoids, steroids, terpenoids and carbohydrates. The results of this study demonstrate the beneficial effects of the stem bark of P. africana in wound care.Entities:
Keywords: Haemostatic activity; Prosopis africana; antibacterial activity; wound care
Year: 2010 PMID： 21188042 PMCID： PMC3003166 DOI： 10.4103/0250-474X.70479
Source DB: PubMed Journal: Indian J Pharm Sci ISSN： 0250-474X Impact factor: 0.975