Literature DB >> 599579

Rapid and accurate determination of the median lethal dose (LD50) and its error with a small computer.

A P Rosiello, J M Essignmann, G N Wogan.   

Abstract

A program for a small digital computer was developed to calculate the median lethal dose (LD50) and its errors. The algorithm employed in the program was based on a method described by Bliss. Modifications introduced by Finney are also discussed. The results indicate a high degree of accuracy compared with calculations performed by Bliss. The accuracy and speed of calculation exceeded those possible with simplified and graphic methods. The data and results for four toxic compounds are presented.

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Year:  1977        PMID： 599579     DOI： 10.1080/15287397709529614

Source DB:  PubMed          Journal:  J Toxicol Environ Health        ISSN： 0098-4108


  8 in total

1.  Pharmacodynamics of levofloxacin against Pseudomonas aeruginosa with reduced susceptibility due to different efflux pumps: do elevated MICs always predict reduced in vivo efficacy?

Authors:  David C Griffith; Erik Corcoran; Denene Lofland; Angela Lee; Deidre Cho; Olga Lomovskaya; Michael N Dudley
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

2.  A new approach to practical acute toxicity testing.

Authors:  D Lorke
Journal:  Arch Toxicol       Date:  1983-12       Impact factor: 5.153

3.  Embryotoxicity of benzothiazoles, benzenesulfohydrazide, and dithiodimorpholine to the chicken embryo.

Authors:  A Korhonen; K Hemminki; H Vainio
Journal:  Arch Environ Contam Toxicol       Date:  1982-11       Impact factor: 2.804

4.  Effects of low-molecular-weight polyguluronate sulfate on experimental urolithiasis in rats.

Authors:  Xia Zhao; Guangli Yu; Nan Yue; Huashi Guan
Journal:  Urol Res       Date:  2007-10-11

5.  In vivo antibacterial activity of RWJ-54428, a new cephalosporin with activity against gram-positive bacteria.

Authors:  David C Griffith; Laurie Harford; Robert Williams; Ving J Lee; Michael N Dudley
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

6.  Hypersensitivity reaction studies of a polyethoxylated castor oil-free, liposome-based alternative paclitaxel formulation.

Authors:  Hongbo Wang; Guang Cheng; Yuan Du; Liang Ye; Wenzhong Chen; Leiming Zhang; Tian Wang; Jingwei Tian; Fenghua Fu
Journal:  Mol Med Rep       Date:  2013-01-04       Impact factor: 2.952

7.  L-carnitine protects C2C12 cells against mitochondrial superoxide overproduction and cell death.

Authors:  Françoise Le Borgne; Gaétan Ravaut; Arnaud Bernard; Jean Demarquoy
Journal:  World J Biol Chem       Date:  2017-02-26

8.  Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine.

Authors:  Jun Chen; Guo-jun Yan; Rong-rong Hu; Qian-wen Gu; Ming-lei Chen; Wei Gu; Zhi-peng Chen; Bao-chang Cai
Journal:  Int J Nanomedicine       Date:  2012-07-26
  8 in total

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