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Literature DB >> 6653034

Formal genetics of isoniazid metabolism in man.

Abstract

Complex segregation analysis of the isoniazid inactivator phenotype has shown the existence of a recessive gene and a multifactorial background. The phenotype is also influenced by age, sex and weight. The relevance of these findings to the grouping of individuals into slow and rapid inactivators is stressed.

Entities: Chemical Species

Mesh：

Substances：
Isoniazid

Year: 1983 PMID： 6653034 DOI： 10.2165/00003088-198308060-00005

Source DB: PubMed Journal: Clin Pharmacokinet ISSN： 0312-5963 Impact factor: 6.447

11 in total

1. Further observations on the determination of the isoniazid inactivator phenotype.

Authors: D A EVANS; P B STOREY; V A McKUSICK
Journal: Bull Johns Hopkins Hosp Date: 1961-01

2. Genetic control of isoniazid metabolism in man.

Authors: D A EVANS; K A MANLEY; V A McKUSICK
Journal: Br Med J Date: 1960-08-13

3. The quantitative determination of isoniazid and para-aminosalicylic acid in body fluids.

Authors: J R MAHER; J M WHITNEY; J S CHAMBERS; D J STANONIS
Journal: Am Rev Tuberc Date: 1957-11

4. Skewness in commingled distributions.

Authors: C J Maclean; N E Morton; R C Elston; S Yee
Journal: Biometrics Date: 1976-09 Impact factor: 2.571

Review 5. Disease and acetylation polymorphism.

Authors: P K Lunde; K Frislid; V Hansteen
Journal: Clin Pharmacokinet Date: 1977 May-Jun Impact factor: 6.447

6. Analysis of family resemblance. 3. Complex segregation of quantitative traits.

Authors: N E Morton; C J MacLean
Journal: Am J Hum Genet Date: 1974-07 Impact factor: 11.025

7. The actylation of sulamethazine and sulfamethoxypyridazine by human subjects.

Authors: T A White; D A Evans
Journal: Clin Pharmacol Ther Date: 1968 Jan-Feb Impact factor: 6.875

8. Analysis of family resemblance. IV. Operational characteristics of segregation analysis.

Authors: C J MacLean; N E Morton; R Lew
Journal: Am J Hum Genet Date: 1975-05 Impact factor: 11.025

9. Complex segregation analysis with pointers.

Authors: J M Lalouel; N E Morton
Journal: Hum Hered Date: 1981 Impact factor: 0.444

Review 10. Clinical pharmacokinetics of isoniazid.

Authors: W W Weber; D W Hein
Journal: Clin Pharmacokinet Date: 1979 Nov-Dec Impact factor: 6.447

11 in total

1. The potential and limitations of personalised medicine in primary care.

Authors: Rhydian Hapgood
Journal: Br J Gen Pract Date: 2003-12 Impact factor: 5.386

Review 2. Hepatic drug metabolism and aging.

Authors: C Durnas; C M Loi; B J Cusack
Journal: Clin Pharmacokinet Date: 1990-11 Impact factor: 6.447

9. Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.

Authors: J W Rodriguez; W G Kirlin; R J Ferguson; M A Doll; K Gray; T D Rustan; M E Lee; K Kemp; P Urso; D W Hein
Journal: Arch Toxicol Date: 1993 Impact factor: 5.153

10. N-acetylation polymorphism of dapsone in a Japanese population.

Authors: Y Horai; T Ishizaki
Journal: Br J Clin Pharmacol Date: 1988-04 Impact factor: 4.335