Literature DB >> 963179

Skewness in commingled distributions.

C J Maclean, N E Morton, R C Elston, S Yee.   

Abstract

A likelihood ratio test is given for distinguishing skewness from commingled distributions, using a power transform to remove skewness appropriately for each of the alternatives tested. The alternative hypotheses postulate that the transformed data are from one normal or a mixture of two or three normal homoscedastic distributions. Since each mixture has unique asymmetry, skewness is estimated simultaneously with the means, proportions and variance of components. Commingling cannot be rigorously proven in this way, as some other transform may provide a better approximation to normality. However, the error of asserting admixture whenever there is skewness has been avoided, and estimates of admixture parameters provide a basis for more conclusive tests in relatives or other populations. Two examples are given, one in which adjustment for skeweness left evidence of commingling.

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Year:  1976        PMID: 963179

Source DB:  PubMed          Journal:  Biometrics        ISSN: 0006-341X            Impact factor:   2.571


  76 in total

1.  Complex segregation analysis of the locus for beta-aminoisobutyric acid excretion (BAIB).

Authors:  S P Simpson; N E Morton
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

2.  Visual search: efficiency continuum or distinct processes?

Authors:  N Haslam; M Porter; L Rothschild
Journal:  Psychon Bull Rev       Date:  2001-12

3.  Linkage analysis of a complex disease through use of admixed populations.

Authors:  Xiaofeng Zhu; Richard S Cooper; Robert C Elston
Journal:  Am J Hum Genet       Date:  2004-05-06       Impact factor: 11.025

4.  Preparatory activations across a distributed cortical network determine production of express saccades in humans.

Authors:  Jordan P Hamm; Kara A Dyckman; Lauren E Ethridge; Jennifer E McDowell; Brett A Clementz
Journal:  J Neurosci       Date:  2010-05-26       Impact factor: 6.167

5.  A familial factor independent of CAG repeat length influences age at onset of Machado-Joseph disease.

Authors:  A L DeStefano; L A Cupples; P Maciel; C Gaspar; J Radvany; D M Dawson; L Sudarsky; L Corwin; P Coutinho; P MacLeod
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

6.  The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study.

Authors:  P P Moll; T L Burns; R M Lauer
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

7.  Simple test statistics for major gene detection: a numerical comparison.

Authors:  P Le Roy; J M Elsen
Journal:  Theor Appl Genet       Date:  1992-03       Impact factor: 5.699

8.  Determinants of plasma uric acid.

Authors:  C L Gulbrandsen; N E Morton; D C Rao; G G Rhoads; A Kagan
Journal:  Hum Genet       Date:  1979-09       Impact factor: 4.132

9.  Major gene analysis of quantitative variation in blood clotting factor X levels.

Authors:  R M Siervogel; R C Elston; R H Lester; J B Graham
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

10.  Major loci for lipoprotein concentrations.

Authors:  N E Morton; C L Gulbrandsen; G G Rhoads; A Kagan; R Lew
Journal:  Am J Hum Genet       Date:  1978-11       Impact factor: 11.025

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