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Literature DB >> 66115

Cytostatic effector cells generated in vivo against M locus determinants.

Abstract

Cytostatic effector cells against M-locus (Mls) determinants were generated in mice by immunization with Mls incompatible lymphocytes. A post-labelling assay of 14C-labelled uridine uptake by macrophage targets was employed to meaure the inhibitory activity of the effector cells. Using lymphocytes from Mls pseudocongenic mice to immunize donors of effector cells, it was confirmed that the cytostatic effect was via the Mls determinants expressed on the macrophage targets. Cytotoxic effector cells against M-locus (Mls) determinants were not detected by the cell-mediated lympholysis assay (CML) in a five day mixed lymphocyte culture (MLC) between Mls incompatible lymphocytes. Specificity of cytotoxic cells generated by culturing in vivo preimmunized responder cells and Mls incompatible stimulator lymphocytes did not correlate with the Mls determinant of the stimulator lymphocytes.

Entities: Chemical Disease Species

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Year: 1977 PMID： 66115 PMCID： PMC1540786

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

7 in total

1. T cell proliferation in the mixed lymphocyte culture does not necessarily result in the generation of cytotoxic T effector cells.

Authors: M Röllinghoff; K Pfizenmeier; H Trostmann; H Wagner
Journal: Eur J Immunol Date: 1975-08 Impact factor: 5.532

Review 2. Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse.

Authors: H Festenstein
Journal: Transplant Rev Date: 1973

3. Antigenic strength investigated by cell-mediated lympholysis in mice.

Authors: K Abbasi; H Festenstein
Journal: Eur J Immunol Date: 1973-07 Impact factor: 5.532

4. Specific lymphocyte-activating determinants expressed on mouse macrophages.

Authors: V Schirrmacher; J Peña-Martinez; H Festenstein
Journal: Nature Date: 1975-05-08 Impact factor: 49.962

5. A new alloantigenic system associated with the Mls locus in the mouse.

Authors: S L Tonkonogy; H J Winn
Journal: J Immunol Date: 1976-03 Impact factor: 5.422

6. The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens.

Authors: M J Bevan
Journal: J Exp Med Date: 1975-12-01 Impact factor: 14.307

7. Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities.

Authors: A Matossian-Rogers; H Festenstein
Journal: J Exp Med Date: 1976-02-01 Impact factor: 14.307

7 in total

8 in total

1. Multi-gene/allele control of Mlsb of CBA/H.

Authors: R E Click; A Adelmann
Journal: Immunogenetics Date: 1989 Impact factor: 2.846

2. Multigene control of Mlsc.

Authors: R E Click; A Adelmann
Journal: Immunogenetics Date: 1988 Impact factor: 2.846

3. Immune responses in vitro, XIV. Undetectability of Mlsb- and Mlsc-encoded products on F1 cells possessing Mlsa or Mlsd.

Authors: R E Click; D Schneider; L A Sitzmann; M M Azar
Journal: Immunogenetics Date: 1984 Impact factor: 2.846

Cytostatic effector cells generated in vivo against M locus determinants.

1. T cell proliferation in the mixed lymphocyte culture does not necessarily result in the generation of cytotoxic T effector cells.

Review 2. Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse.

3. Antigenic strength investigated by cell-mediated lympholysis in mice.

4. Specific lymphocyte-activating determinants expressed on mouse macrophages.

5. A new alloantigenic system associated with the Mls locus in the mouse.

6. The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens.

7. Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities.

1. Multi-gene/allele control of Mlsb of CBA/H.

2. Multigene control of Mlsc.

3. Immune responses in vitro, XIV. Undetectability of Mlsb- and Mlsc-encoded products on F1 cells possessing Mlsa or Mlsd.

4. Soluble Mlsa antigens: stimulatory effect in vitro versus suppressive effect in vivo.

5. Modification of the anti-tumour immune response by suppressor gene products of lymphoid cells.

6. Association of the lymphoproliferative disease inducer gene Arp with autoimmunity and resistance to tumour growth.

7. Alloimmune interactions of a lymphoproliferative disease-inducer gene Arp and linkage to Pep-7.

8. Cytostasis against self-antigens.