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Literature DB >> 55455

Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities.

Abstract

The effect of preimmunization of CBA/H mice with M locus and H-2 incompatible lymphocytes was examined on the in vitro generation of cytotoxic cells to both types of targets. Preimmunization with M locus did not help to generate cytotoxic cells to M-locus targets; however, the anti-H-2 cytotoxicity of M-locus-preimmunized lymphocytes was suppressed between the 6th and 19th day after preimmunization. In contrast, preimmunization with H-2 incompatibility produced an amplified lytic anti-H-2 response. The possible mechanisms are discussed.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1976 PMID： 55455 PMCID： PMC2190111 DOI： 10.1084/jem.143.2.456

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

1. Disappearance of specifically mlc-responsive lymphocytes in cba mice injected with cells from the h-2-compatible, m-antigen-incompatible strain c3h.

Authors: H Jacobsson; B Lilliehöök; H Blomgren
Journal: Scand J Immunol Date: 1975 Impact factor: 3.487

Review 2. Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse.

Authors: H Festenstein
Journal: Transplant Rev Date: 1973

3. The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment.

Authors: D J Schendel; B J Alter; F H Bach
Journal: Transplant Proc Date: 1973-12 Impact factor: 1.066

4. Antigenic strength investigated by cell-mediated lympholysis in mice.

Authors: K Abbasi; H Festenstein
Journal: Eur J Immunol Date: 1973-07 Impact factor: 5.532

5. Effects of presensitization on the mixed lymphocyte reaction of rat spleen cell cultures.

Authors: M Virolainen; P Häyry; V Defendi
Journal: Transplantation Date: 1969-08 Impact factor: 4.939

6. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

Authors: D C Shreffler; C S David
Journal: Adv Immunol Date: 1975 Impact factor: 3.543

7. Pertinent features of M locus determinants including revised nomenclature and strain distribution.

Authors: H Festenstein
Journal: Transplantation Date: 1974-12 Impact factor: 4.939

8. Specifically decreased MLC response of lymphocytes from CBA mice injected with cells from the H-2-compatible, M-antigen-incompatible strain C3H. Lack of such effect after injection of H-2-disparate C3H-hybrid cells.

Authors: B Lilliehöök; H Jacobsson; H Blomgren
Journal: Scand J Immunol Date: 1975 Impact factor: 3.487

7. Regulatory mechanisms in cell-mediated immune responses. V. H-2 homology requirements for the production of a minor locus-induced suppressor factor.

Authors: D L Kastner; R R Rich; L Chu; S S Rich
Journal: J Exp Med Date: 1977-10-01 Impact factor: 14.307

8. Generation of primary cytotoxic lymphocytes against non-major histocompatibility complex antigens by anti-Ia serum plus complement-treated lymphocytes.

Authors: C E Hayes; S Macphail; F H Bach
Journal: J Exp Med Date: 1980-05-01 Impact factor: 14.307

8 in total

Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities.

1. Disappearance of specifically mlc-responsive lymphocytes in cba mice injected with cells from the h-2-compatible, m-antigen-incompatible strain c3h.

Review 2. Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse.

3. The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment.

4. Antigenic strength investigated by cell-mediated lympholysis in mice.

5. Effects of presensitization on the mixed lymphocyte reaction of rat spleen cell cultures.

6. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

7. Pertinent features of M locus determinants including revised nomenclature and strain distribution.

8. Specifically decreased MLC response of lymphocytes from CBA mice injected with cells from the H-2-compatible, M-antigen-incompatible strain C3H. Lack of such effect after injection of H-2-disparate C3H-hybrid cells.

9. Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.

10. Role of H-2 lymphocyte-defined and serologically-defined components in the generation of cytotoxic lymphocytes.

1. Population movement and fate of autoreactive V beta 6+ T cells in Mls-1a mice.

2. Cytostatic effector cells generated in vivo against M locus determinants.

3. Modification of the anti-tumour immune response by suppressor gene products of lymphoid cells.

4. Contrasting effects of H-2 and Mls immunization on the polyclonal mitogenicity of murine lymphocytes.

5. T-cell receptor Vbeta gene expression in experimental lupus nephritis.

6. Suppressor T cells activated in a primary in vitro response to non-major histocompatibility alloantigens.

7. Regulatory mechanisms in cell-mediated immune responses. V. H-2 homology requirements for the production of a minor locus-induced suppressor factor.

8. Generation of primary cytotoxic lymphocytes against non-major histocompatibility complex antigens by anti-Ia serum plus complement-treated lymphocytes.