Literature DB >> 77201

Cytostasis against self-antigens.

L De Giorgi, A Matossian-Rogers, H Festenstein.   

Abstract

Effector cells from mice of the C57Bl/10 congenic series, alloimmunized against K end- or D end-identical I region incompatible lymphocytes, were cytostatic for tumour and macrophage targets bearing syngeneic K-end and D-end antigens. If incompatibility during immunization was restricted to the I-B subregion only, cytostasis was directed against K end syngeneic antigens; further incompatibility in the I region was required to obtain cytostasis against D-end self-antigens. Cytostasis against self-antigens was also obtained after immunization with syngeneic tumour cells; in one instance this was directed against syngeneic K-end antigens only. The implications of these findings in relation to neoplastic change and autoimmune damage are discussed.

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Year:  1978        PMID: 77201      PMCID: PMC1541228     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN: 0009-9104            Impact factor:   4.330


  21 in total

1.  The genetics of cytostasis [proceedings].

Authors:  L de Giorgi; G Biasi; H Festenstein
Journal:  Folia Biol (Praha)       Date:  1976       Impact factor: 0.906

2.  Tumour-specific antigen related to rat histocompatibility antigens.

Authors:  J G Bowen; R W Baldwin
Journal:  Nature       Date:  1975-11-06       Impact factor: 49.962

3.  Cell-mediated cytotoxicity to SV40-specific tumour-associated antigens.

Authors:  G Trinchieri; D P Aden; B B Knowles
Journal:  Nature       Date:  1976-05-27       Impact factor: 49.962

4.  Blocking of syngeneic effector T cells by soluble tumour antigens.

Authors:  F Plata; J P Levy
Journal:  Nature       Date:  1974-05-17       Impact factor: 49.962

5.  Specific cytostatic effect of lymph node cells from normal and T cell-deficient mice on syngeneic tumor target cells in vitro and its specific abrogation by body fluids from syngeneic tumor-bearing mice.

Authors:  E Chia; H Festenstein
Journal:  Eur J Immunol       Date:  1973-08       Impact factor: 5.532

6.  Further evidence for the involvement of thymus-processed lymphocytes in syngeneic tumor cell cytolysis.

Authors:  F Plata; E Gomard; J C Leclerc; J P Levy
Journal:  J Immunol       Date:  1973-09       Impact factor: 5.422

7.  Mechanism of immunologically specific killing of tumour cells by macrophages.

Authors:  R Evans; P Alexander
Journal:  Nature       Date:  1972-03-24       Impact factor: 49.962

8.  Cytostasis of lymphoma cells in suspension: probable non-thymic origin of the cytostatic lymphoid cells in mice bearing mys -induced tumors.

Authors:  A Senik; L de Giorgi; E Gomard; J P Levy
Journal:  Int J Cancer       Date:  1974-09-15       Impact factor: 7.396

9.  Cell-mediated anti-tumor immunity in oncornavirus-induced tumors: specific cytostasis of tumor cells by spleen amd lymph-node cells.

Authors:  A Senik; L de Giorgi; J P Levy
Journal:  Int J Cancer       Date:  1974-09-15       Impact factor: 7.396

10.  Cell-mediated immune reaction against tumors induced by oncornaviruses. II. Nature of the effector cells in tumor-cell cytolysis.

Authors:  J C Leclerc; E Gomard; F Plata; J P Levy
Journal:  Int J Cancer       Date:  1973-03-15       Impact factor: 7.396

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  1 in total

1.  Modification of the anti-tumour immune response by suppressor gene products of lymphoid cells.

Authors:  L De Giorgi; A Matossian-Rogers; H Festenstein
Journal:  Immunology       Date:  1979-04       Impact factor: 7.397

  1 in total

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