Literature DB >> 6611152

The effect of mitogenic lectins and monoclonal antibodies on intracellular free calcium concentration in human T-lymphocytes.

K O'Flynn, D C Linch, P E Tatham.   

Abstract

The effect of mitogenic lectins and the mitogenic antibody UCHT1 on the cytoplasmic free Ca2+ concentration ( [Ca2+]i) in human lymphocytes was investigated by using the fluorescent Ca2+-indicator quin2 . Phytohaemagglutinin, concanavalin A and UCHT1 increased [Ca2+]i in T-cells to a maximum level within 2 min. No T-cell response was seen with poke weed mitogen. None of the mitogens affected non-T-cell [Ca2+]i.

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Year:  1984        PMID： 6611152      PMCID： PMC1153525          DOI： 10.1042/bj2190661

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

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Authors:  M H Freedman; M C Raff
Journal:  Nature       Date:  1975-05-29       Impact factor: 49.962

2.  Role of adherent cells in immune responses to phytohemagglutinin and concanavalin A.

Authors:  M P Arala-Chaves; L Hope; J H Korn; H Fudenberg
Journal:  Eur J Immunol       Date:  1978-02       Impact factor: 5.532

3.  An improved rosetting assay for detection of human T lymphocytes.

Authors:  M E Kaplan; C Clark
Journal:  J Immunol Methods       Date:  1974-07       Impact factor: 2.303

4.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

5.  The mixed leucocyte reaction: studies using leucocytes from unrelated human subjects.

Authors:  M W Elves
Journal:  Vox Sang       Date:  1969-02       Impact factor: 2.144

6.  Characterization of a human B cell-specific antigen (B2) distinct from B1.

Authors:  L M Nadler; P Stashenko; R Hardy; A van Agthoven; C Terhorst; S F Schlossman
Journal:  J Immunol       Date:  1981-05       Impact factor: 5.422

7.  A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage.

Authors:  C S Abramson; J H Kersey; T W LeBien
Journal:  J Immunol       Date:  1981-01       Impact factor: 5.422

8.  OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

Authors:  J P Van Wauwe; J R De Mey; J G Goossens
Journal:  J Immunol       Date:  1980-06       Impact factor: 5.422

9.  A monoclonal antibody blocking human T cell function.

Authors:  E L Reinherz; R E Hussey; S F Schlossman
Journal:  Eur J Immunol       Date:  1980-10       Impact factor: 5.532

10.  Detection of human histocompatibility (HLA) antigens with an indirect rosette microassay.

Authors:  F Indiveri; B S Wilson; M A Pellegrino; S Ferrone
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303
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  10 in total

1.  Modulation of calcium fluxes in Jurkat T cells by myristic acid. Inhibition is independent of membrane potential and intracellular pH.

Authors:  T Nordström; T Mustelin; T Pessa-Morikawa; L C Andersson
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

2.  Different pathways of human T-cell activation revealed by PHA-P and PHA-M.

Authors:  K O'Flynn; M Russul-Saib; I Ando; D L Wallace; P C Beverley; A W Boylston; D C Linch
Journal:  Immunology       Date:  1986-01       Impact factor: 7.397

3.  Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

Authors:  C H June; J A Ledbetter; P S Rabinovitch; P J Martin; P G Beatty; J A Hansen
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

4.  Respective contribution of intracellular calcium release and extracellular calcium influx for interleukin-2 synthesis in activated T-cell hybrids.

Authors:  D B Williams; M A Perera; K J Dorrington; M H Klein
Journal:  Immunology       Date:  1990-03       Impact factor: 7.397

5.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

6.  Monoclonal antibodies increase intracellular Ca2+ in sea urchin spermatozoa.

Authors:  J S Trimmer; R W Schackmann; V D Vacquier
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

7.  The effects of pertussis toxin on human T lymphocytes.

Authors:  E A Macintyre; P E Tatham; R Abdul-Gaffar; D C Linch
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397

8.  Characterization of a T-lymphocyte membrane protein involved in T-cell function: its contribution to T-cell recognition or cellular interaction.

Authors:  L Schrod; H Schaefer; R Burger
Journal:  Immunology       Date:  1986-04       Impact factor: 7.397

9.  Inositol lipid metabolism in human T lymphocytes activated via the T3 complex.

Authors:  S Cockcroft; J R Lamb; E D Zanders
Journal:  Immunology       Date:  1987-02       Impact factor: 7.397

10.  T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.

Authors:  A Tunnacliffe; J E Sims; T H Rabbitts
Journal:  EMBO J       Date:  1986-06       Impact factor: 11.598
  10 in total

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