Literature DB >> 2417941

Different pathways of human T-cell activation revealed by PHA-P and PHA-M.

K O'Flynn, M Russul-Saib, I Ando, D L Wallace, P C Beverley, A W Boylston, D C Linch.   

Abstract

Antigen-specific T-cell activation is mediated via the CD3-Ti (antigen receptor) complex, and monoclonal antibodies to both CD3 and Ti cause a rapid rise in intracellular Ca2+. This calcium mobilization is not inhibited by monoclonal antibodies to CD2. The rise in calcium mobilization induced by purified PHA (PHA-P) does not occur in a cell line which lacks CD2 expression, and can be blocked in other T cells by anti-CD2 antibodies. A combination of monoclonal antibodies to different epitopes of CD2 causes calcium mobilization and mitogenesis. Reagent grade PHA (PHA-M) induces calcium moblization in cells that lack CD2, and its effects in other T cells cannot be blocked by anti-CD2 antibodies. The effects of PHA-P and PHA-M are thus mediated predominantly through different activation pathways.

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Year:  1986        PMID： 2417941      PMCID： PMC1453876     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  15 in total

1.  Expression of an antigen associated with acute lymphoblastic leukemia in human leukemia-lymphoma cell lines.

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Journal:  J Natl Cancer Inst       Date:  1978-06       Impact factor: 13.506

2.  Investigation of early T cell activation: analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration.

Authors:  K O'Flynn; E D Zanders; J R Lamb; P C Beverley; D L Wallace; P E Tatham; W J Tax; D C Linch
Journal:  Eur J Immunol       Date:  1985-01       Impact factor: 5.532

3.  The effect of mitogenic lectins and monoclonal antibodies on intracellular free calcium concentration in human T-lymphocytes.

Authors:  K O'Flynn; D C Linch; P E Tatham
Journal:  Biochem J       Date:  1984-04-15       Impact factor: 3.857

4.  Identification and functional characterization of two distinct epitopes on the human T cell surface protein Tp50.

Authors:  P J Martin; G Longton; J A Ledbetter; W Newman; M P Braun; P G Beatty; J A Hansen
Journal:  J Immunol       Date:  1983-07       Impact factor: 5.422

5.  An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.

Authors:  S C Meuer; R E Hussey; M Fabbi; D Fox; O Acuto; K A Fitzgerald; J C Hodgdon; J P Protentis; S F Schlossman; E L Reinherz
Journal:  Cell       Date:  1984-04       Impact factor: 41.582

6.  A human T cell tumor which expresses the putative T cell antigen receptor.

Authors:  A W Boylston; R D Goldin; C S Moore
Journal:  Eur J Immunol       Date:  1984-03       Impact factor: 5.532

7.  Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.

Authors:  P C Beverley; R E Callard
Journal:  Eur J Immunol       Date:  1981-04       Impact factor: 5.532

8.  Calcium transport and calcium-ATPase activity in human lymphocyte plasma membrane vesicles.

Authors:  A H Lichtman; G B Segel; M A Lichtman
Journal:  J Biol Chem       Date:  1981-06-25       Impact factor: 5.157

9.  Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

Authors:  F Sanchez-Madrid; A M Krensky; C F Ware; E Robbins; J L Strominger; S J Burakoff; T A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

10.  Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

Authors:  M J Weiss; J F Daley; J C Hodgdon; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205
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  13 in total

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Journal:  Hepatology       Date:  2010-10-26       Impact factor: 17.425

2.  In vitro OKT3-induced mitogenesis in selenium-deficient patients on a diet for phenylketonuria.

Authors:  R J Collins; P J Boyle; A E Clague; A E Barr; S C Latham
Journal:  Biol Trace Elem Res       Date:  1991-09       Impact factor: 3.738

3.  Deletion of a CD2-like gene, 8-DR, from African swine fever virus affects viral infection in domestic swine.

Authors:  M V Borca; C Carrillo; L Zsak; W W Laegreid; G F Kutish; J G Neilan; T G Burrage; D L Rock
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

4.  Complexing of the CD-3 subunit by a monoclonal antibody activates a microtubule-associated protein 2 (MAP-2) serine kinase in Jurkat cells.

Authors:  C Hanekom; A Nel; C Gittinger; A Rheeder; G Landreth
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

5.  Phytohaemagglutinin responsiveness of peripheral lymphocytes and survival in patients with primary breast cancer.

Authors:  A Burford-Mason; G M Gyte; S M Watkins
Journal:  Breast Cancer Res Treat       Date:  1989-07       Impact factor: 4.872

6.  Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

Authors:  B Seed; A Aruffo
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

7.  Inhibition of T-cell antigen receptor-mediated transmembrane signaling by protein kinase C activation.

Authors:  R T Abraham; S N Ho; T J Barna; K M Rusovick; D J McKean
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

8.  Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.

Authors:  Amandine Crequer; Anja Troeger; Etienne Patin; Cindy S Ma; Capucine Picard; Vincent Pedergnana; Claire Fieschi; Annick Lim; Avinash Abhyankar; Laure Gineau; Ingrid Mueller-Fleckenstein; Monika Schmidt; Alain Taieb; James Krueger; Laurent Abel; Stuart G Tangye; Gérard Orth; David A Williams; Jean-Laurent Casanova; Emmanuelle Jouanguy
Journal:  J Clin Invest       Date:  2012-08-01       Impact factor: 14.808

9.  Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3.

Authors:  M L Dustin; D Olive; T A Springer
Journal:  J Exp Med       Date:  1989-02-01       Impact factor: 14.307

10.  l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-β, Production by Neonatal Regulatory T Lymphocytes.

Authors:  Hong-Ren Yu; Ching-Chang Tsai; Ling-Sai Chang; Hsin-Chun Huang; Hsin-Hsin Cheng; Jiu-Yao Wang; Jiunn-Ming Sheen; Ho-Chang Kuo; Kai-Sheng Hsieh; Ying-Hsien Huang; Kuender D Yang; Te-Yao Hsu
Journal:  Front Immunol       Date:  2017-04-25       Impact factor: 7.561
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