Literature DB >> 6608451

A human T cell tumor which expresses the putative T cell antigen receptor.

A W Boylston, R D Goldin, C S Moore.   

Abstract

A monoclonal antibody (mAb) called H1-2D4 which reacts only with the T cell line HPB-ALL and not with other T cell lines, normal or activated peripheral blood cells, B lymphoblasts (B-LCL), or thymocytes has been developed. This mAb cocaps the T3 antigen on HPB-ALL and anti-T3 mAb cocaps the antigen which reacts with H1-2D4. Purified H1-2D4 precipitates a heterodimer from HPB-ALL cells which has components with molecular weights of 51 000 and 39 000. The properties of the molecule recognized by H1-2D4 suggest that it is the HPB-ALL equivalent of the putative human T cell antigen receptor.

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Year:  1984        PMID： 6608451     DOI： 10.1002/eji.1830140313

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  6 in total

1.  Different pathways of human T-cell activation revealed by PHA-P and PHA-M.

Authors:  K O'Flynn; M Russul-Saib; I Ando; D L Wallace; P C Beverley; A W Boylston; D C Linch
Journal:  Immunology       Date:  1986-01       Impact factor: 7.397

2.  Quantitative relationship between T3 and the T-cell antigen receptor on a human leukaemic line.

Authors:  R D Goldin; R A Boulton; A W Boylston
Journal:  Immunology       Date:  1985-10       Impact factor: 7.397

3.  The effects of pertussis toxin on human T lymphocytes.

Authors:  E A Macintyre; P E Tatham; R Abdul-Gaffar; D C Linch
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397

4.  Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

Authors:  D A Cantrell; A A Davies; M J Crumpton
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

5.  Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex.

Authors:  A Moretta; G Pantaleo; M Lopez-Botet; L Moretta
Journal:  J Exp Med       Date:  1985-09-01       Impact factor: 14.307

6.  Phaseolus vulgaris phytohaemagglutinin (PHA) binds to the human T lymphocyte antigen receptor.

Authors:  O P Chilson; A W Boylston; M J Crumpton
Journal:  EMBO J       Date:  1984-12-20       Impact factor: 11.598
  6 in total

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