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Literature DB >> 3863788

Quantitative relationship between T3 and the T-cell antigen receptor on a human leukaemic line.

Abstract

The T-cell antigen receptor complex consists of an idiotypic molecule, Ti, and T3. We have investigated the relationship between Ti and T3 on a leukaemic line HPB-ALL. This has shown that the two molecules are expressed on the cell surface in equal numbers, and that a similar stoichiometric relationship is seen on sublines of HPB-ALL selected for diminished expression of Ti. Furthermore, the degrees of modulation and rates of resynthesis of Ti and T3 following modulation were very similar, regardless of whether anti-Ti or anti-T3 was used to produce the modulation. This work strongly suggests that the expression of Ti and T3 are under common control.

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Year: 1985 PMID： 3863788 PMCID： PMC1453702

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

16 in total

1. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

Authors: P L Ey; S J Prowse; C R Jenkin
Journal: Immunochemistry Date: 1978-07

2. A method of trace iodination of proteins for immunologic studies.

Authors: P J McConahey; F J Dixon
Journal: Int Arch Allergy Appl Immunol Date: 1966

3. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

Authors: A Weiss; J D Stobo
Journal: J Exp Med Date: 1984-11-01 Impact factor: 14.307

4. The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides.

Authors: J Borst; J E Coligan; H Oettgen; S Pessano; R Malin; C Terhorst
Journal: Nature Date: 1984 Nov 29-Dec 5 Impact factor: 49.962

5. Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.

Authors: H D Royer; O Acuto; M Fabbi; R Tizard; K Ramachandran; J E Smart; E L Reinherz
Journal: Cell Date: 1984-12 Impact factor: 41.582

Quantitative relationship between T3 and the T-cell antigen receptor on a human leukaemic line.

1. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

2. A method of trace iodination of proteins for immunologic studies.

3. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

4. The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides.

5. Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.

6. A monoclonal antibody blocking human T cell function.

7. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.

8. Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes.

9. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.

10. Functional properties of continuously cultured human T lymphocytes.

1. Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas.