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Literature DB >> 6607033

Properties of novel beta-lactamase produced by Bacteroides fragilis.

A Yotsuji, S Minami, M Inoue, S Mitsuhashi.

Abstract

Bacteroides fragilis strains were isolated from clinical specimens. B. fragilis G-237 was highly resistant to beta-lactam antibiotics due to beta-lactamase production. The purified enzyme from this strain gave a single protein band on polyacrylamide gel electrophoresis. The isoelectric point was 4.8, and the molecular weight was estimated to be 26,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme activity was inhibited by p-chloromercuribenzoate and iodine but not by clavulanic acid or sulbactam. The purified enzyme showed a unique substrate profile by hydrolyzing at a high rate most of the cephalosporins, including cephamycin derivatives, penicillins, and imipenem (formerly imipemide, N-formimidoyl thienamycin, or MK 0787).

Entities: Chemical Species

Mesh：

Substances：

Year: 1983 PMID： 6607033 PMCID： PMC185409 DOI： 10.1128/AAC.24.6.925

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

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Journal: Antimicrob Agents Chemother Date: 1975-09 Impact factor: 5.191

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Journal: Biochem J Date: 1970-07 Impact factor: 3.857

10. Susceptibility of anaerobic bacteria to 23 antimicrobial agents.

Authors: V L Sutter; S M Finegold
Journal: Antimicrob Agents Chemother Date: 1976-10 Impact factor: 5.191

41 in total

1. Biochemical characterization of the metallo-beta-lactamase CcrA from Bacteroides fragilis TAL3636.

Authors: Y Yang; B A Rasmussen; K Bush
Journal: Antimicrob Agents Chemother Date: 1992-05 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1989-03 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1990-11 Impact factor: 5.191

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Journal: Clin Microbiol Rev Date: 1991-10 Impact factor: 26.132

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Journal: Antimicrob Agents Chemother Date: 1991-02 Impact factor: 5.191

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Authors: Karen Bush; George A Jacoby
Journal: Antimicrob Agents Chemother Date: 2009-12-07 Impact factor: 5.191

7. Biochemical characterization of a beta-lactamase that hydrolyzes penems and carbapenems from two Serratia marcescens isolates.

Authors: Y J Yang; P J Wu; D M Livermore
Journal: Antimicrob Agents Chemother Date: 1990-05 Impact factor: 5.191

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Authors: P Mastrantonio; R Cardines; P Spigaglia
Journal: Antimicrob Agents Chemother Date: 1996-04 Impact factor: 5.191