Literature DB >> 6604881

The regulation of 5-hydroxytryptamine release from superfused synaptosomes by 5-hydroxytryptamine and its immediate precursors.

H A Suter, K J Collard.   

Abstract

The effect of L-tryptophan, 5-hydroxy-L-tryptophan (5-HTP), and 5-hydroxytryptamine (5-HT) on the K+-evoked release of [3H]5-HT from superfused rat brain synaptosomes was studied. 5-HT at concentrations above 10 nM significantly inhibited the K+-evoked release of [3H]5-HT. A slight enhancement of [3H]5-HT release was observed at a concentration of 5nM. In contrast tryptophan at a concentration of 10 nM significantly enhanced [3H]5-HT release with little effect at higher concentrations. 5-HTP did not significantly effect [3H]5-HT release. The results confirm previous findings that 5-HT inhibits its own release from nerve endings, and demonstrate that low concentrations of tryptophan in the synaptic region may act as a positive feedback regulator of 5-HT release.

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Year:  1983        PMID： 6604881     DOI： 10.1007/bf00964729

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  11 in total

1.  The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors:  E G GRAY; V P WHITTAKER
Journal:  J Anat       Date:  1962-01       Impact factor: 2.610

2.  A method for concurrent measurement of picomole quantities of acetylcholine, choline, dopamine, norepinephrine, serotonin, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, tryptophan, tyrosine, glycine, aspartate, glutamate, alanine, and gamma-aminobutyric acid in single tissue samples from different areas of rat central nervous system.

Authors:  J E Smith; J D Lane; P A Shea; W J McBride; M H Aprison
Journal:  Anal Biochem       Date:  1975-03       Impact factor: 3.365

3.  Regional distribution of high-affinity L-tryptophan uptake in rat brain.

Authors:  S H Höckel; W E Müller; U Wollert
Journal:  Neurosci Lett       Date:  1978-04       Impact factor: 3.046

4.  Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons.

Authors:  A J Mandell; S Knapp
Journal:  Fed Proc       Date:  1977-07

5.  Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake.

Authors:  M J Kuhar; R H Roth; G K Aghajanian
Journal:  J Pharmacol Exp Ther       Date:  1972-04       Impact factor: 4.030

6.  Serotonin-receptor-mediated modulation of Ca2+-dependent 5-hydroxytryptamine release from neurones of the rat brain cortex.

Authors:  M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-11       Impact factor: 3.000

7.  Serotonin release is modulated by presynaptic autoreceptors.

Authors:  F Cerrito; M Raiteri
Journal:  Eur J Pharmacol       Date:  1979-08-15       Impact factor: 4.432

8.  The stimulus-induced release of unmetabolized 5-hydroxytryptamine from superfused rat brain synaptosomes.

Authors:  K J Collard; D M Cassidy; M A Pye; R M Taylor
Journal:  J Neurosci Methods       Date:  1981-08       Impact factor: 2.390

9.  K+-evoked [3H]-5-HT release from rat frontal cortex slices: the effect of 5-HT agonists and antagonists.

Authors:  I Mounsey; K A Brady; J Carroll; R Fisher; D N Middlemiss
Journal:  Biochem Pharmacol       Date:  1982-01-01       Impact factor: 5.858

10.  The stimulus-induced release of 5-hydroxytryptamine and tryptophan from superfused rat brain synaptosomes.

Authors:  K J Collard; T N Evans; H A Suter; L S Wilkinson
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575
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