Literature DB >> 488172

Serotonin release is modulated by presynaptic autoreceptors.

F Cerrito, M Raiteri.   

Abstract

The existence of presynaptic autoreceptors controlling the release of 5-hydroxytryptamine (5HT) from serotonergic nerve endings was investigated utilizing superfused hypothalamic synaptosomes. Extracellular 5HT reduced the high K+-induced release of previously accumulated 3H-5HT. The central 5HT receptor blocker methiothepin counteracted the inhibitory effect of 5HT. Other 5HT antagonists (cyproheptadine, methysergide and mianserin) were inactive and may therefore act preferentially at the postsynaptic receptors.

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Year:  1979        PMID： 488172     DOI： 10.1016/0014-2999(79)90506-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  40 in total

1.  Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat.

Authors:  S Herges; D A Taylor
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

2.  Evidence for presynaptic location of inhibitory 5-HT1D beta-like autoreceptors in the guinea-pig brain cortex.

Authors:  M Bühlen; K Fink; C Böing; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-02       Impact factor: 3.000

3.  Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro.

Authors:  B Driessen; W Reimann
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

4.  Behavioral and neurochemical effects of repeated MDMA administration during late adolescence in the rat.

Authors:  Brittney M Cox; Mrudang M Shah; Teri Cichon; Manuel E Tancer; Matthew P Galloway; David M Thomas; Shane A Perrine
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2013-10-10       Impact factor: 5.067

5.  Pharmacological profile of a potential anxiolytic: AP159, a new benzothieno-pyridine derivative.

Authors:  T Nagatani; T Yamamoto; K Takao; S Hashimoto; K Kasahara; T Sugihara; S Ueki
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

6.  Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis.

Authors:  T Sharp; S R Bramwell; S Hjorth; D G Grahame-Smith
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

7.  Phentolamine blocks presynaptic serotonin autoreceptors in rabbit and rat brain cortex.

Authors:  N Limberger; M R Fischer; T Wichmann; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

8.  Neuropeptide Y enhances the inhibitory effects of clonidine on 3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat.

Authors:  M Martire; K Fuxe; G Pistritto; P Preziosi; L F Agnati
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

9.  Extracellular 5-hydroxytryptamine inhibits 5-hydroxytryptamine release from rat brain cortex slices.

Authors:  M Göthert; G Weinheimer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

10.  Noradrenaline inhibits central serotonin release through alpha 2-adrenoceptors located on serotonergic nerve terminals.

Authors:  G Maura; A Gemignani; M Raiteri
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-09       Impact factor: 3.000
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