Literature DB >> 1959916

Differential methylation at the 5' and the 3' CCGG sites flanking the X chromosomal hypervariable DXS255 locus.

R W Hendriks1, M E Kraakman, R G Mensink, R K Schuurman.   

Abstract

The degree of methylation at the 5' and 3' CCGG sequences flanking the variable number of tandem repeat (VNTR) region of the DXS255 locus at Xp11.22 was analysed separately in several haematopoietic cell lineages. The 5' CCGG site on active chromosomes was found to be completely methylated in B and T lymphocytes and granulocytes. Methylation of the 5' site on inactive X chromosomes differed between females (0%-60%), but was consistent in different cell lineages obtained from individual females. In contrast, methylation at the 3' CCGG site on active chromosomes was found to vary in B lymphocytes (40%-100%), whereas complete methylation was found in T lymphocytes and granulocytes. The extent of methylation on inactive X chromosomes was found to differ significantly between B lymphocytes (17%), T lymphocytes (54%) and granulocytes (82%). Thus, methylation at the 5' CCGG site seems to be primarily related to the status of X chromosome inactivation, whereas methylation at the 3' CCGG site is mainly subject to cell-lineage-specific influences.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1959916     DOI： 10.1007/bf00204939

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  35 in total

Review 1.  Genetics of human X-linked immunodeficiency diseases.

Authors:  R W Hendriks; R K Schuurman
Journal:  Clin Exp Immunol       Date:  1991-08       Impact factor: 4.330

2.  High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

Authors:  F Antequera; J Boyes; A Bird
Journal:  Cell       Date:  1990-08-10       Impact factor: 41.582

3.  Isolation and characterization of a human variable copy number tandem repeat at Xcen-p11.22.

Authors:  N J Fraser; Y Boyd; I Craig
Journal:  Genomics       Date:  1989-07       Impact factor: 5.736

4.  Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

Authors:  D H Keith; J Singer-Sam; A D Riggs
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

5.  A highly informative X-chromosome probe, M27 beta, can be used for the determination of tumour clonality.

Authors:  G Abrahamson; N J Fraser; J Boyd; I Craig; J S Wainscoat
Journal:  Br J Haematol       Date:  1990-03       Impact factor: 6.998

6.  Expression of the gene defect in X-linked agammaglobulinemia.

Authors:  M E Conley; P Brown; A R Pickard; R H Buckley; D S Miller; W H Raskind; J W Singer; P J Fialkow
Journal:  N Engl J Med       Date:  1986-08-28       Impact factor: 91.245

Review 7.  X-chromosome inactivation and developmental patterns in mammals.

Authors:  M F Lyon
Journal:  Biol Rev Camb Philos Soc       Date:  1972-01

8.  Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency.

Authors:  M E Conley; A Lavoie; C Briggs; P Brown; C Guerra; J M Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

9.  Tissue-specific levels of human glucose-6-phosphate dehydrogenase correlate with methylation of specific sites at the 3' end of the gene.

Authors:  G Battistuzzi; M D'Urso; D Toniolo; G M Persico; L Luzzatto
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

10.  Wiskott-Aldrich syndrome: cellular impairments and their implication for carrier detection.

Authors:  J T Prchal; A J Carroll; J F Prchal; W M Crist; H W Skalka; W J Gealy; J Harley; A Malluh
Journal:  Blood       Date:  1980-12       Impact factor: 22.113
View more
  7 in total

1.  Different patterns of X inactivation in MZ twins discordant for red-green color-vision deficiency.

Authors:  A L Jørgensen; J Philip; W H Raskind; M Matsushita; B Christensen; V Dreyer; A G Motulsky
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

2.  Is skewed X inactivation responsible for symptoms in female carriers for adrenoleucodystrophy?

Authors:  E Watkiss; T Webb; S Bundey
Journal:  J Med Genet       Date:  1993-08       Impact factor: 6.318

3.  X chromosome inactivation and the diagnosis of X linked disease in females.

Authors:  R M Brown; G K Brown
Journal:  J Med Genet       Date:  1993-03       Impact factor: 6.318

4.  Interaction of incontinentia pigmenti and factor VIII mutations in a female with biased X inactivation, resulting in haemophilia.

Authors:  R Coleman; S A Genet; J I Harper; A O Wilkie
Journal:  J Med Genet       Date:  1993-06       Impact factor: 6.318

5.  Clonal analysis of human tumors with M27 beta, a highly informative polymorphic X chromosomal probe.

Authors:  M F Fey; H J Peter; H L Hinds; A Zimmermann; S Liechti-Gallati; H Gerber; H Studer; A Tobler
Journal:  J Clin Invest       Date:  1992-05       Impact factor: 14.808

Review 6.  Pyridoxine-refractory congenital sideroblastic anaemia with evidence for autosomal inheritance: exclusion of linkage to ALAS2 at Xp11.21 by polymorphism analysis.

Authors:  P E Jardine; P D Cotter; S A Johnson; E J Fitzsimons; L Tyfield; P W Lunt; D F Bishop
Journal:  J Med Genet       Date:  1994-03       Impact factor: 6.318

7.  Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia.

Authors:  A Arnold; M F Brown; P Ureña; R D Gaz; E Sarfati; T B Drüeke
Journal:  J Clin Invest       Date:  1995-05       Impact factor: 14.808
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.