Literature DB >> 6593156

Combined analysis of genetic segregation and linkage under an oligogenic model.

C J MacLean, N E Morton, S Yee.   

Abstract

For traits with incomplete penetrance, simultaneous segregation analysis and linkage analysis may offer increased information. Since the numerical properties of the mixed model are a drawback in this more complicated analysis, a second locus is substituted for the polygenic component yielding a simpler and more tractable oligogenic model. While less realistic, the simpler model is not easily discriminated from the mixed model, particularly when used on affection data rather than quantitative traits. Calculations for combined linkage and segregation analysis are described for nuclear families with pointers to account for sampling scheme.

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Year:  1984        PMID： 6593156     DOI： 10.1016/0010-4809(84)90013-2

Source DB:  PubMed          Journal:  Comput Biomed Res        ISSN： 0010-4809


  17 in total

1.  Association testing in a linked region using large pedigrees.

Authors:  Rita M Cantor; Gary K Chen; Päivi Pajukanta; Kenneth Lange
Journal:  Am J Hum Genet       Date:  2005-01-18       Impact factor: 11.025

2.  Numerical comparison between powers of maximum likelihood and analysis of variance methods for QTL detection in progeny test designs: the case of monogenic inheritance.

Authors:  P Le Roy; J M Elsen
Journal:  Theor Appl Genet       Date:  1995-01       Impact factor: 5.699

3.  Bayesian analysis of linkage between genetic markers and quantitative trait loci. II. Combining prior knowledge with experimental evidence.

Authors:  I Hoeschele; P M Vanraden
Journal:  Theor Appl Genet       Date:  1993-02       Impact factor: 5.699

4.  Logarithm of odds (lods) for linkage in complex inheritance.

Authors:  N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

5.  Comparison of parametric and nonparametric methods to map oligogenes by linkage.

Authors:  P Liò; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

6.  Estimation of segregation and linkage parameters in simulated data. II. Simultaneous estimation with one linked marker.

Authors:  R A Price; P L Kramer; D L Pauls; K K Kidd
Journal:  Am J Hum Genet       Date:  1989-07       Impact factor: 11.025

7.  Assessing the role of HLA-linked and unlinked determinants of disease.

Authors:  N Risch
Journal:  Am J Hum Genet       Date:  1987-01       Impact factor: 11.025

8.  A segregation and linkage study of classical and nonclassical 21-hydroxylase deficiency.

Authors:  S L Sherman; C E Aston; N E Morton; P W Speiser; M I New
Journal:  Am J Hum Genet       Date:  1988-06       Impact factor: 11.025

9.  Genetic mapping of the 21-hydroxylase locus: estimation of small recombination frequencies.

Authors:  C E Aston; S L Sherman; N E Morton; P W Speiser; M I New
Journal:  Am J Hum Genet       Date:  1988-09       Impact factor: 11.025

10.  Family studies of non-insulin-dependent diabetes mellitus in South Indians.

Authors:  M I McCarthy; G A Hitman; D C Shields; N E Morton; C Snehalatha; V Mohan; A Ramachandran; M Viswanathan
Journal:  Diabetologia       Date:  1994-12       Impact factor: 10.122
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