Literature DB >> 3137812

Genetic mapping of the 21-hydroxylase locus: estimation of small recombination frequencies.

C E Aston1, S L Sherman, N E Morton, P W Speiser, M I New.   

Abstract

The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.

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Year:  1988        PMID： 3137812      PMCID： PMC1715389     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  16 in total

1.  Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.

Authors:  J M Lalouel; L Le Mignon; M Simon; R Fauchet; M Bourel; D C Rao; N E Morton
Journal:  Am J Hum Genet       Date:  1985-07       Impact factor: 11.025

2.  Nonuniform recombination within the human beta-globin gene cluster.

Authors:  B S Weir; W G Hill
Journal:  Am J Hum Genet       Date:  1986-05       Impact factor: 11.025

3.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

4.  Report of the Committee on the Genetic Constitution of Chromosomes 5 and 6.

Authors:  L U Lamm; B Olaisen
Journal:  Cytogenet Cell Genet       Date:  1985

Review 5.  Recent advances in 21-hydroxylase deficiency.

Authors:  M I New; L S Levine
Journal:  Annu Rev Med       Date:  1984       Impact factor: 13.739

6.  Kinship mapping of multilocus systems.

Authors:  N E Morton; S P Simpson
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

7.  Combined analysis of genetic segregation and linkage under an oligogenic model.

Authors:  C J MacLean; N E Morton; S Yee
Journal:  Comput Biomed Res       Date:  1984-10

8.  Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.

Authors:  P C White; D Grossberger; B J Onufer; D D Chaplin; M I New; B Dupont; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

9.  Gene order and gene distances in the HLA region studied by the haplotype method.

Authors:  B Olaisen; P Teisberg; R Jonassen; E Thorsby; T Gedde-Dahl
Journal:  Ann Hum Genet       Date:  1983-10       Impact factor: 1.670

10.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205
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  3 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

3.  Molecular detection of genetic defects in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a study of 27 families.

Authors:  D Strumberg; B P Hauffa; B Horsthemke; H Grosse-Wilde
Journal:  Eur J Pediatr       Date:  1992-11       Impact factor: 3.183
  3 in total

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