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Literature DB >> 6585812

Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).

K L Behar, D L Rothman, R G Shulman, O A Petroff, J W Prichard.

Abstract

1H NMR was used to monitor lactate production and clearance during hypoxemia and recovery in the rabbit brain at the relatively low magnetic-field strength of 1.89 T. An array of conventional physiological variables were recorded simultaneously with spectrum acquisition, including the electroencephalogram and electrocardiogram. The sensitivity and spectral resolution achieved at this field strength should be applicable to studies of human brain pathophysiology in the large-bore magnets now available.

Entities: Chemical Disease Species

Mesh：

Substances：
Lactates
Lactic Acid

Year: 1984 PMID： 6585812 PMCID： PMC345093 DOI： 10.1073/pnas.81.8.2517

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Human erythrocyte metabolism studies by 1H spin echo NMR.

Authors: F F Brown; I D Campbell; P W Kuchel; D C Rabenstein
Journal: FEBS Lett Date: 1977-10-01 Impact factor: 4.124

2. Developmental changes of creatine kinase metabolism in rat brain.

Authors: W I Norwood; J S Ingwall; C R Norwood; E T Fossel
Journal: Am J Physiol Date: 1983-03

3. Noninvasive investigation of cerebral ischemia by phosphorus nuclear magnetic resonance.

Authors: D T Delpy; R E Gordon; P L Hope; D Parker; E O Reynolds; D Shaw; M D Whitehead
Journal: Pediatrics Date: 1982-08 Impact factor: 7.124

4. High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.

Authors: K L Behar; J A den Hollander; M E Stromski; T Ogino; R G Shulman; O A Petroff; J W Prichard
Journal: Proc Natl Acad Sci U S A Date: 1983-08 Impact factor: 11.205

5. Detection of 31P nuclear magnetic resonance signals in brain by in vivo and freeze-trapped assays.

Authors: B Chance; Y Nakase; M Bond; J S Leigh; G McDonald
Journal: Proc Natl Acad Sci U S A Date: 1978-10 Impact factor: 11.205

6. The measurement of free and N-acetylated aspartic acids in the nervous system.

Authors: M C Fleming; O H Lowry
Journal: J Neurochem Date: 1966-09 Impact factor: 5.372

7. Cerebral metabolic studies in vivo by 31P NMR.

Authors: J W Prichard; J R Alger; K L Behar; O A Petroff; R G Shulman
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

8. A 31P nuclear magnetic resonance in vivo study of cerebral ischaemia in the gerbil.

Authors: K R Thulborn; G H du Boulay; L W Duchen; G Radda
Journal: J Cereb Blood Flow Metab Date: 1982-09 Impact factor: 6.200

9. What causes infarction in ischemic brain?: The Robert Wartenberg Lecture.

Authors: F Plum
Journal: Neurology Date: 1983-02 Impact factor: 9.910

10. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy.

Authors: E B Cady; A M Costello; M J Dawson; D T Delpy; P L Hope; E O Reynolds; P S Tofts; D R Wilkie
Journal: Lancet Date: 1983-05-14 Impact factor: 79.321

7 in total

Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).

1. Human erythrocyte metabolism studies by 1H spin echo NMR.

2. Developmental changes of creatine kinase metabolism in rat brain.

3. Noninvasive investigation of cerebral ischemia by phosphorus nuclear magnetic resonance.

4. High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.

5. Detection of 31P nuclear magnetic resonance signals in brain by in vivo and freeze-trapped assays.

6. The measurement of free and N-acetylated aspartic acids in the nervous system.

7. Cerebral metabolic studies in vivo by 31P NMR.

8. A 31P nuclear magnetic resonance in vivo study of cerebral ischaemia in the gerbil.

9. What causes infarction in ischemic brain?: The Robert Wartenberg Lecture.

10. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy.

Review 1. Metabolomics as a tool for cardiac research.

2. Spatially localized 1H NMR spectra of metabolites in the human brain.

3. Hypoxia induced metabolism dysfunction of rat astrocytes in primary cell cultures.

4. 1H homonuclear editing of rat brain using semiselective pulses.

5. Alterations in brain metabolism induced by chronic morphine treatment: NMR studies in rat CNS.

6. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo.

7. In vivo solvent-suppressed localized hydrogen nuclear magnetic resonance spectroscopy: a window to metabolism?