Literature DB >> 12938859

Alterations in brain metabolism induced by chronic morphine treatment: NMR studies in rat CNS.

Sushil K Sharma1, Kiran Yashpal, Marian E Fundytus, Françoise Sauriol, James L Henry, Terence J Coderre.   

Abstract

High-resolution (500 MHz) multiresonance/multinuclear proton (1H) nuclear magnetic resonance (NMR) spectroscopy was used to detect metabolic changes and cellular injury in the rat brain stem and spinal cord following chronic morphine treatment. Compensatory changes were observed in glycine, glutamate, and inositols in the brain stem, but not the spinal cord, of chronic morphine-treated rats. In spinal cord, increases were detected in lactate and N-acetyl-aspartate (NAA), suggesting that there is anaerobic glycolysis, plasma membrane damage, and altered pH preferentially in the spinal cord of chronic morphine-treated rats.

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Year:  2003        PMID： 12938859     DOI： 10.1023/a:1024996415795

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  19 in total

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Journal:  J Neurochem       Date:  1994-03       Impact factor: 5.372
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  4 in total

1.  Neurochemical changes in brain induced by chronic morphine treatment: NMR studies in thalamus and somatosensory cortex of rats.

Authors:  Yun Xiang; Hongchang Gao; Hang Zhu; Ninglei Sun; Yuanye Ma; Hao Lei
Journal:  Neurochem Res       Date:  2006-10       Impact factor: 3.996

2.  Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance.

Authors:  Wen-Jinn Liaw; Cheng-Ming Tsao; Go-Shine Huang; Chin-Chen Wu; Shung-Tai Ho; Jhi-Joung Wang; Yuan-Xiang Tao; Hao-Ai Shui
Journal:  PLoS One       Date:  2014-01-02       Impact factor: 3.240

3.  Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains.

Authors:  Mª Luisa Soto-Montenegro; Verónica García-Vázquez; Nicolás Lamanna-Rama; Gonzalo López-Montoya; Manuel Desco; Emilio Ambrosio
Journal:  Sci Rep       Date:  2022-03-17       Impact factor: 4.379

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Journal:  Metabolomics       Date:  2020-11-07       Impact factor: 4.290
  4 in total

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