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Literature DB >> 6583673

Brain-specific genes have identifier sequences in their introns.

R J Milner, F E Bloom, C Lai, R A Lerner, J G Sutcliffe.

Abstract

The 82-nucleotide identifier (ID) sequence is present in the rat genome in 1-1.5 X 10(5) copies and in cDNA clones of precursors of brain-specific mRNAs. One brain-specific gene contains more than one ID sequence in its introns. There is an excess of ID sequences to brain genes, and some ID sequences appear to have been inserted as mobile elements into other genetic locations. Therefore, brain genes contain ID sequences in their introns, but not all ID sequences are located in brain gene introns. A brain ID consensus sequence has been obtained by comparing 8 ID nucleotide sequences.

Entities: Species

Mesh：

Substances：
Nerve Tissue Proteins
DNA

Year: 1984 PMID： 6583673 PMCID： PMC344905 DOI： 10.1073/pnas.81.3.713

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. The rat serum albumin gene: analysis of cloned sequences.

Authors: T D Sargent; J R Wu; J M Sala-Trepat; R B Wallace; A A Reyes; J Bonner
Journal: Proc Natl Acad Sci U S A Date: 1979-07 Impact factor: 11.205

2. Gene regulation for higher cells: a theory.

Authors: R J Britten; E H Davidson
Journal: Science Date: 1969-07-25 Impact factor: 47.728

3. Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides.

Authors: J G Sutcliffe; R J Milner; T M Shinnick; F E Bloom
Journal: Cell Date: 1983-07 Impact factor: 41.582

4. Polymorphism near the rat prolactin gene caused by insertion of an Alu-like element.

Authors: L A Schuler; J L Weber; J Gorski
Journal: Nature Date: 1983 Sep 8-14 Impact factor: 49.962

5. Primary structure and evolution of rat growth hormone gene.

Authors: A Barta; R I Richards; J D Baxter; J Shine
Journal: Proc Natl Acad Sci U S A Date: 1981-08 Impact factor: 11.205

6. Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements.

Authors: G Galli; H Hofstetter; M L Birnstiel
Journal: Nature Date: 1981-12-17 Impact factor: 49.962

7. Speculations on RNA splicing.

Authors: P A Sharp
Journal: Cell Date: 1981-03 Impact factor: 41.582

8. Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40.

Authors: P Gruss; C J Lai; R Dhar; G Khoury
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

9. Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNA.

Authors: R C Peterson; J L Doering; D D Brown
Journal: Cell Date: 1980-05 Impact factor: 41.582

10. Nucleotide sequence of Xenopus borealis oocyte 5S DNA: comparison of sequences that flank several related eucaryotic genes.

Authors: L J Korn; D D Brown
Journal: Cell Date: 1978-12 Impact factor: 41.582

40 in total

1. Neuronal untranslated BC1 RNA: targeted gene elimination in mice.

Authors: Boris V Skryabin; Valentina Sukonina; Ursula Jordan; Lars Lewejohann; Norbert Sachser; Ilham Muslimov; Henri Tiedge; Jürgen Brosius
Journal: Mol Cell Biol Date: 2003-09 Impact factor: 4.272

2. 5-Methylcytidylic modification of in vitro transcript from the rat identifier sequence; evidence that the transcript forms a tRNA-like structure.

Authors: K Sakamoto; N Okada
Journal: Nucleic Acids Res Date: 1985-10-25 Impact factor: 16.971

Brain-specific genes have identifier sequences in their introns.

1. The rat serum albumin gene: analysis of cloned sequences.

2. Gene regulation for higher cells: a theory.

3. Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides.

4. Polymorphism near the rat prolactin gene caused by insertion of an Alu-like element.

5. Primary structure and evolution of rat growth hormone gene.

6. Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements.

7. Speculations on RNA splicing.

8. Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40.

9. Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNA.

10. Nucleotide sequence of Xenopus borealis oocyte 5S DNA: comparison of sequences that flank several related eucaryotic genes.

1. Neuronal untranslated BC1 RNA: targeted gene elimination in mice.

2. 5-Methylcytidylic modification of in vitro transcript from the rat identifier sequence; evidence that the transcript forms a tRNA-like structure.

3. Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content.

4. Expression of small cytoplasmic transcripts of the rat identifier element in vivo and in cultured cells.

5. Stable accumulation of a rat truncated repeat transcript in Xenopus oocytes.

6. The neuronal identifier element is a cis-acting positive regulator of gene expression.

Review 7. Structure, function, and evolution of adenovirus-associated RNA: a phylogenetic approach.

8. A composite transposon 3' to the cow fetal globin gene binds a sequence specific factor.

9. Conservation and variation in the large scale organisation of the globin gene domains of duck and chicken.

10. Nature and origin of the RNA associated with simian virus 40 large tumor antigen.