Literature DB >> 7312050

Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements.

G Galli, H Hofstetter, M L Birnstiel.   

Abstract

The split promoter sequences of a tRNALeuCUG gene of Xenopus laevis have been mapped to nucleotides 13-20 and 51-64 of the tRNALeu coding sequences. The sequences closely coincide with two conserved sequence blocks present in all eukaryotic tRNA genes. The two conserved sequence blocks were found to be exchangeable between tRNA genes as chimaeric tRNAMet--tRNALeu genes proved transcriptionally active. Furthermore, two prokaryotic tRNA genes exhibiting strong homologies with the two blocks yielded specific transcripts when tested in an eukaryotic transcriptional system.

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Year:  1981        PMID： 7312050     DOI： 10.1038/294626a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  197 in total

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Review 8.  Incorporation of Non-Canonical Amino Acids.

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9.  RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system.

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Review 10.  Controlling translation via modulation of tRNA levels.

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