Literature DB >> 658270

Cocarcinogens of the diterpene ester type from Croton flavens L. and esophageal cancer in Curaçao.

J Weber, E Hecker.   

Abstract

From the roots of Croton flavens L., 3 highly irritant and tumor promoting Croton factors F1--F3 and the corresponding 3 cryptic Croton factors F'1--F'3 were isolated and characterized as novel esters of 16-hydroxy- and 4-deoxy-16-hydroxyphorbol, respectively. These findings suggest that tumor promoters of the phorbol ester type, ingested through the widespread and frequent use of Croton flavens according to local habits, may be causally related to the well recognized high rate of esophageal cancer on Curaçao.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 658270     DOI： 10.1007/BF01947253

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  New highly irritant euphorbia factors from latex of Euphorbia tirucalli L.

Authors:  G Fürstenberger; E Hecker
Journal:  Experientia       Date:  1977-08-15

2.  Definitions and terminology in cancer (tumor) etiology-an analysis aiming at proposals for a current internationally standardized terminology;.

Authors:  E Hecker
Journal:  Int J Cancer       Date:  1976-07-15       Impact factor: 7.396

Review 3.  Phorbolesters--the irritants and cocarcinogens of Croton Tiglium L.

Authors:  E Hecker; R Schmidt
Journal:  Fortschr Chem Org Naturst       Date:  1974

4.  [On the biologically active compounds of euphorbiaceae. I. Skinirritant and cocarcinogenic factors from Euphorbia cooperi N.E.Br (author's transl)].

Authors:  M Gschwendt; E Hecker
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973-12-28

5.  Active principles of croton oil. X. Preparation of tritium labeled croton oil factor A1 and other tritium labeled phorbol derivatives.

Authors:  G Kreibich; E Hecker
Journal:  Z Krebsforsch       Date:  1970

6.  Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles.

Authors:  L J Dunham; R H Sheets; J F Morton
Journal:  J Natl Cancer Inst       Date:  1974-11       Impact factor: 13.506

7.  Carcinogenicity of extracts of selected plants from Curacao after oral and subcutaneous administration to rodents.

Authors:  R W O'Gara; C Lee; J F Morton
Journal:  J Natl Cancer Inst       Date:  1971-06       Impact factor: 13.506

8.  Plants associated with esophageal cancer cases in Curacao.

Authors:  J F Morton
Journal:  Cancer Res       Date:  1968-11       Impact factor: 12.701

9.  [On the chemistry of phorbol. IV. Polybenzoate and acetate of phorbol and phorbol-3-ol and functional derivatives of the allyl grouping of phorbol].

Authors:  H U Schairer; H W Thielmann; M Gschwendt; G Kreibich; R Schmidt; E Hecker
Journal:  Z Naturforsch B       Date:  1968-11       Impact factor: 1.047
  9 in total
  11 in total

Review 1.  Protein kinase C as a tumor suppressor.

Authors:  Alexandra C Newton
Journal:  Semin Cancer Biol       Date:  2017-05-02       Impact factor: 15.707

2.  Esophageal cancer in Kashmir--an assessment.

Authors:  M Siddiqi; R Preussmann
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

Review 3.  Protein kinase C: perfectly balanced.

Authors:  Alexandra C Newton
Journal:  Crit Rev Biochem Mol Biol       Date:  2018-04       Impact factor: 8.250

4.  Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi.

Authors:  Monica C O Campos; Kelly Salomão; Denise B Castro-Pinto; Leonor L Leon; Helene S Barbosa; Maria Aparecida M Maciel; Solange L de Castro
Journal:  Parasitol Res       Date:  2010-08-03       Impact factor: 2.289

5.  Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.

Authors:  K Goerttler; H Loehrke; J Schweizer; B Hesse
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1980

6.  Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives.

Authors:  H Fujiki; M Mori; T Sugimura; M Hirota; H Ohigashi; K Koshimizu
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

7.  Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.

Authors:  H Fujiki; M Mori; M Nakayasu; M Terada; T Sugimura; R E Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

Review 8.  Multistage carcinogenesis: implications for risk estimation.

Authors:  H Yamasaki
Journal:  Cancer Metastasis Rev       Date:  1988-04       Impact factor: 9.264

9.  Promoting action of croton oil on gastrocarcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Authors:  N Matsukura; T Kawachi; T Sano; K Sasajima; T Sugimura
Journal:  J Cancer Res Clin Oncol       Date:  1979-04-12       Impact factor: 4.553

10.  PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.

Authors:  J E Trosko; B Dawson; C C Chang
Journal:  Environ Health Perspect       Date:  1981-01       Impact factor: 9.031
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.