Literature DB >> 6257504

PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.

J E Trosko, B Dawson, C C Chang.   

Abstract

Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB could act, epigenetically, as a teratogen and a carcinogenic promoter.

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Year:  1981        PMID： 6257504      PMCID： PMC1568655          DOI： 10.1289/ehp.8137179

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  27 in total

1.  A new hypothesis on mitotic control mechanism in eukaryotic cells: cell-specific mitosis-inhibiting protein excretion hypothesis.

Authors:  H Onda
Journal:  J Theor Biol       Date:  1979-04-07       Impact factor: 2.691

2.  Cellular interactions of phorbol myristate acetate in tumor promotion.

Authors:  A Sivak; B L Van Duuren
Journal:  Chem Biol Interact       Date:  1971-11       Impact factor: 5.192

Review 3.  Mitotic and functional homeostasis: a speculative review.

Authors:  W S Bullough
Journal:  Cancer Res       Date:  1965-11       Impact factor: 12.701

4.  Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells.

Authors:  A W Murray; D J Fitzgerald
Journal:  Biochem Biophys Res Commun       Date:  1979-11-28       Impact factor: 3.575

5.  The biochemistry of preneoplasia in mouse skin.

Authors:  R K Boutwell
Journal:  Cancer Res       Date:  1976-07       Impact factor: 12.701

6.  The mechanism of action and interaction of regulators of cell replication.

Authors:  D A Gilbert
Journal:  Biosystems       Date:  1978-08       Impact factor: 1.973

7.  Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

Authors:  L P Yotti; C C Chang; J E Trosko
Journal:  Science       Date:  1979-11-30       Impact factor: 47.728

8.  Gastric carcinoma promoted by alkaline reflux gastritis -- with special reference to bile and other surfactants as promoters of postoperative gastric cancer.

Authors:  L Domellöf
Journal:  Med Hypotheses       Date:  1979-04       Impact factor: 1.538

9.  Correlation of cocarcinogenic activity among n-alkanes with their physical effects on phospholipid micelles.

Authors:  A W Horton; D N Eshleman; A R Schuff; W H Perman
Journal:  J Natl Cancer Inst       Date:  1976-02       Impact factor: 13.506

10.  Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells.

Authors:  S Mondal; D W Brankow; C Heidelberger
Journal:  Cancer Res       Date:  1976-07       Impact factor: 12.701
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  5 in total

Review 1.  Possible effect of neonatal polybrominated biphenyl exposure on the developmental abilities of children.

Authors:  D W Nebert; J D Elashoff; K R Wilcox
Journal:  Am J Public Health       Date:  1983-03       Impact factor: 9.308

2.  Inhibition of metabolic cooperation by cigarette smoke condensate and its fractions in V-79 Chinese hamster lung fibroblasts.

Authors:  T G Hartman; J D Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

Review 3.  Brain Disorders and Chemical Pollutants: A Gap Junction Link?

Authors:  Marc Mesnil; Norah Defamie; Christian Naus; Denis Sarrouilhe
Journal:  Biomolecules       Date:  2020-12-31

Review 4.  Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication.

Authors:  I V Budunova; G M Williams
Journal:  Cell Biol Toxicol       Date:  1994-04       Impact factor: 6.691

5.  Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures.

Authors:  K S Kang; M R Wilson; T Hayashi; C C Chang; J E Trosko
Journal:  Environ Health Perspect       Date:  1996-02       Impact factor: 9.031
  5 in total

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