Literature DB >> 6580258

Genetics of human S-adenosylhomocysteine hydrolase. A new polymorphism in man.

S Bissbort, K Bender, T F Wienker, K H Grzeschik.   

Abstract

A specific staining procedure for the demonstration of S-adenosylhomocysteine hydrolase (SAHH, EC 3.3.1.1) is given. The enzyme has a broad tissue distribution and is also present in erythrocytes. The SAHH gene is polymorphic in the population of southwest Germany with two common alleles: SAHH*1 = 0.96 and SAHH*2 = 0.04. Family studies resulted in the expected segregation ratios. No evidence for close linkage with a total of 25 marker loci was found. But information from human mouse somatic-cell hybrids led to the localization of the SAHH gene to human chromosome 20, thereby confirming the findings of Hershfield and Francke (1982).

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Year:  1983        PMID： 6580258     DOI： 10.1007/bf00285031

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  2 in total

1.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

2.  The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20.

Authors:  M S Hershfield; U Francke
Journal:  Science       Date:  1982-05-14       Impact factor: 47.728
  2 in total
  5 in total

Review 1.  The map of chromosome 20.

Authors:  N E Simpson
Journal:  J Med Genet       Date:  1988-12       Impact factor: 6.318

2.  A general method for visualizing enzymes releasing adenosine or adenosine-5'-monophosphate.

Authors:  C A Friedrich; S Chakravarti; R E Ferrell
Journal:  Biochem Genet       Date:  1984-06       Impact factor: 1.890

3.  Linkage relationship between the genes for adenosine deaminase and S-adenosyl-homocysteine hydrolase on human chromosome 20.

Authors:  S Bissbort; H W Hitzeroth; C T van den Berg; T F Wienker
Journal:  Hum Genet       Date:  1987-11       Impact factor: 4.132

4.  Regional localization of the human genes for S-adenosylhomocysteine hydrolase (cen----q131) and adenosine deaminase (q131----qter) on chromosome 20.

Authors:  T Mohandas; R S Sparkes; E J Suh; M S Hershfield
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

5.  Gene frequencies of S-adenosylhomocysteine hydrolase (SAHH) in a Japanese population.

Authors:  K Akiyama; S Nakamura; K Abe
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132
  5 in total

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