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Literature DB >> 6577204

CpG frequency in large DNA segments.

Abstract

The relationship between the deficiency of CpG dinucleotides and the coding-noncoding segments of DNA has been examined. Analysis of five human alpha-like globin DNA sequences and five human beta-like globin DNA sequences reveal that there is no apparent difference between protein coding and non-coding portions of DNA. Rather CpG deficiency appears to be a property of long contiguous segments of DNA consisting of several genes and their intergenic regions. Thus we propose that CpG deficiency is not involved with translation or transcription but rather is related to chromosomal constraints.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6577204 DOI： 10.1007/bf02099976

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

14 in total

1. Doublet frequency analysis of fractionated vertebrate nuclear DNA.

Authors: G J Russell; P M Walker; R A Elton; J H Subak-Sharpe
Journal: J Mol Biol Date: 1976-11 Impact factor: 5.469

2. DNA modification mechanisms and gene activity during development.

Authors: R Holliday; J E Pugh
Journal: Science Date: 1975-01-24 Impact factor: 47.728

3. Dipeptide frequencies in proteins and the CpG deficiency in vertebrate DNA.

Authors: E Bullock; R A Elton
Journal: J Mol Evol Date: 1972-12 Impact factor: 2.395

4. An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbor base sequences.

Authors: H Subak-Sharpe; R R Bürk; L V Crawford; J M Morrison; J Hay; H M Keir
Journal: Cold Spring Harb Symp Quant Biol Date: 1966

Review 5. DNA methylation--a regulatory signal in eukaryotic gene expression.

Authors: W Doerfler
Journal: J Gen Virol Date: 1981-11 Impact factor: 3.891

6. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene.

Authors: N J Proudfoot; A Gil; T Maniatis
Journal: Cell Date: 1982-12 Impact factor: 41.582

7. DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues.

Authors: L H van der Ploeg; R A Flavell
Journal: Cell Date: 1980-04 Impact factor: 41.582

8. The universal dinucleotide asymmetry rules in DNA and the amino acid codon choice.

Authors: R Nussinov
Journal: J Mol Evol Date: 1981 Impact factor: 2.395

9. DNA methylation and the frequency of CpG in animal DNA.

Authors: A P Bird
Journal: Nucleic Acids Res Date: 1980-04-11 Impact factor: 16.971

10. Codons and nearest-neighbor nucleotide pairs in mammalian messenger RNA.

Authors: T H Jukes
Journal: J Mol Evol Date: 1978-06-20 Impact factor: 2.395

8 in total

1. Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage.

Authors: E Beutler; T Gelbart; J H Han; J A Koziol; B Beutler
Journal: Proc Natl Acad Sci U S A Date: 1989-01 Impact factor: 11.205

CpG frequency in large DNA segments.

1. Doublet frequency analysis of fractionated vertebrate nuclear DNA.

2. DNA modification mechanisms and gene activity during development.

3. Dipeptide frequencies in proteins and the CpG deficiency in vertebrate DNA.

4. An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbor base sequences.

Review 5. DNA methylation--a regulatory signal in eukaryotic gene expression.

6. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene.

7. DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues.

8. The universal dinucleotide asymmetry rules in DNA and the amino acid codon choice.

9. DNA methylation and the frequency of CpG in animal DNA.

10. Codons and nearest-neighbor nucleotide pairs in mammalian messenger RNA.

1. Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage.

2. Comparative analysis of genes encoding methyl coenzyme M reductase in methanogenic bacteria.

3. CG dinucleotide clusters in MHC genes and in 5' demethylated genes.

4. Intercodon dinucleotides affect codon choice in plant genes.

5. Analysis of CpG suppression in methylated and nonmethylated species.

6. Mammalian mutation pressure, synonymous codon choice, and mRNA degradation.

7. Sequence divergence of an archaebacterial gene cloned from a mesophilic and a thermophilic methanogen.

8. Over- and under-representation of short oligonucleotides in DNA sequences.