Literature DB >> 6576222

Polyamines enhance readthrough of the UGA termination codon in a mammalian messenger RNA.

M M Hryniewicz, R A Vonder Haar.   

Abstract

The polyamines spermidine and spermine stimulate the readthrough of the UGA termination codon of rabbit beta-globin mRNA when it is translated in a rabbit reticulocyte cell-free system. The other major polyamine, putrescine, does not show this effect. The polyamine induced readthrough is specific for UGA as the UAA termination codon of alpha-globin mRNA is not read through and general translational misreading errors are not occurring in the presence of spermidine or spermine. The probable mechanism of this effect and some possible regulatory implications are discussed.

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Year:  1983        PMID： 6576222     DOI： 10.1007/bf00330661

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  43 in total

1.  Enhanced differential synthesis of proteins in a mammalian cell-free system by addition of polyamines.

Authors:  J F Atkins; J B Lewis; C W Anderson; R F Gesteland
Journal:  J Biol Chem       Date:  1975-07-25       Impact factor: 5.157

2.  The readthrough protein A1 is essential for the formation of viable Q beta particles.

Authors:  H Hofstetter; H J Monstein; C Weissmann
Journal:  Biochim Biophys Acta       Date:  1974-12-06

3.  The UGA codon in vitro: chain termination and suppression.

Authors:  P Model; R E Webster; N D Zinder
Journal:  J Mol Biol       Date:  1969-07-14       Impact factor: 5.469

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Genetic code: the 'nonsense' triplets for chain termination and their suppression.

Authors:  S Brenner; A O Stretton; S Kaplan
Journal:  Nature       Date:  1965-06-05       Impact factor: 49.962

6.  Regulation of the escherichia coli tryptophan operon by readthrough of UGA termination codons.

Authors:  H Engelberg-Kulka; L Dekel; M Israeli-Reches
Journal:  Biochem Biophys Res Commun       Date:  1981-02-27       Impact factor: 3.575

7.  Usage of the three termination codons: compilation and analysis of the known eukaryotic and prokaryotic translation termination sequences.

Authors:  J Kohli; H Grosjean
Journal:  Mol Gen Genet       Date:  1981

8.  A UGA termination suppression tRNATrp active in rabbit reticulocytes.

Authors:  A I Geller; A Rich
Journal:  Nature       Date:  1980-01-03       Impact factor: 49.962

9.  Codon specificity of UGA suppressor tRNATrp from Escherichia coli.

Authors:  R H Buckingham; C G Kurland
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor.

Authors:  M R Capecchi; G N Gussin
Journal:  Science       Date:  1965-07-23       Impact factor: 47.728
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  5 in total

Review 1.  Programmed translational frameshifting.

Authors:  P J Farabaugh
Journal:  Microbiol Rev       Date:  1996-03

Review 2.  Roles of polyamines in translation.

Authors:  Thomas E Dever; Ivaylo P Ivanov
Journal:  J Biol Chem       Date:  2018-10-15       Impact factor: 5.157

3.  A recoding element that stimulates decoding of UGA codons by Sec tRNA[Ser]Sec.

Authors:  Michael T Howard; Mark W Moyle; Gaurav Aggarwal; Bradley A Carlson; Christine B Anderson
Journal:  RNA       Date:  2007-04-24       Impact factor: 4.942

4.  Translational recoding as a feedback controller: systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift.

Authors:  Claudia Rato; Svetlana R Amirova; Declan G Bates; Ian Stansfield; Heather M Wallace
Journal:  Nucleic Acids Res       Date:  2011-02-07       Impact factor: 16.971

Review 5.  Stop making sense: or Regulation at the level of termination in eukaryotic protein synthesis.

Authors:  R P Valle; M D Morch
Journal:  FEBS Lett       Date:  1988-08-01       Impact factor: 4.124
  5 in total

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