Literature DB >> 6559104

Influence of human interferon-alpha therapy on cytotoxic functions of blood lymphocytes. Studies on lectin-dependent cellular cytotoxicity, antibody-dependent cellular cytotoxicity, and natural killer cell activity.

S Einhorn, H Blomgren, H Strander, J Wasserman.   

Abstract

Various cytotoxic functions of blood lymphocytes were studied in 101 patients undergoing daily treatment with human interferon-alpha (IFN). Antibody-dependent cellular cytotoxicity and lectin-dependent cellular cytotoxicity were not altered to any major extent after 1 day or 1 week of IFN therapy. After 3 and 6 months of treatment a decrease in these functions was observed in most patients. Natural killer cell activity increased following the first injection of IFN and remained elevated during 1 year of IFN therapy.

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Year:  1983        PMID： 6559104     DOI： 10.1007/bf00199235

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  21 in total

1.  The effect of interferon on lymphocyte-mediated effector cell functions: selective enhancement of natural killer cells.

Authors:  I Heron; M Hokland; A Møller-Larsen; K Berg
Journal:  Cell Immunol       Date:  1979-01       Impact factor: 4.868

2.  Large-scale production of human leukocyte interferon containing 10(8) units per ml.

Authors:  K Cantell; S Hirvonen
Journal:  J Gen Virol       Date:  1978-06       Impact factor: 3.891

3.  Role of interferon in regulation of cytotoxicity by natural killer cells and macrophages.

Authors:  R B Herberman; J R Ortaldo; J Y Djeu; H T Holden; J Jett; N P Lang; M Rubinstein; S Pestka
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

4.  In vitro enhancement of natural and antibody-dependent lymphocyte-mediated cytotoxicity against tumor target cells by interferon.

Authors:  M J Droller; H Borg; P Perlmann
Journal:  Cell Immunol       Date:  1979-10       Impact factor: 4.868

5.  Interferon and spontaneous cytotoxicity in man. II. Studies in patients receiving exogenous leukocyte interferon.

Authors:  S Einhorn; H Blomgren; H Strander
Journal:  Acta Med Scand       Date:  1978

6.  Augmentation of human K-cell activity with interferon.

Authors:  J R Ortaldo; S Pestka; R B Slease; M Rubinstein; R B Herberman
Journal:  Scand J Immunol       Date:  1980       Impact factor: 3.487

7.  Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-alpha.

Authors:  S Einhorn; C Jarstrand
Journal:  Cancer Immunol Immunother       Date:  1982       Impact factor: 6.968

8.  Interferon in cancer: Faith, hope and reality.

Authors:  H Strander; S Einhorn
Journal:  Am J Clin Oncol       Date:  1982-06       Impact factor: 2.339

9.  Effect of an intramuscular injection of human leukocyte interferon on blood leukocyte counts and proportions of lymphocytes forming E, EA and EAC rosettes.

Authors:  S Einhorn; H Blomgren; H Strander
Journal:  Int Arch Allergy Appl Immunol       Date:  1980

10.  Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.

Authors:  G Trinchieri; D Santoli
Journal:  J Exp Med       Date:  1978-05-01       Impact factor: 14.307
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  7 in total

1.  Influence of alpha-interferon therapy on blood lymphoid cells. Studies on antibody production, mixed lymphocyte culture response, mitogen responsiveness and 2'-5'oligoadenylate synthetase activity.

Authors:  S Einhorn; P Ling; N Einhorn; H Strander; J Wasserman
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

2.  Cytokine production in whole blood cell cultures of patients undergoing therapy with biological response modifiers or 5-fluorouracil.

Authors:  U Elsässer-Beile; S von Kleist; A Lindenthal; R Birken; H Gallati; J S Mönting
Journal:  Cancer Immunol Immunother       Date:  1993-08       Impact factor: 6.968

3.  Functions of human neutrophilic granulocytes after in vivo exposure to interferon alpha.

Authors:  S Einhorn; C Jarstrand
Journal:  Infect Immun       Date:  1984-03       Impact factor: 3.441

4.  Surface markers and cytotoxic activities of lymphocytes in monoclonal gammopathy of undetermined significance and untreated multiple myeloma. Increased phytohemagglutinin-induced cellular cytotoxicity and inverted helper/suppressor cell ratio are features common to both diseases.

Authors:  G De Rossi; G De Sanctis; V Bottari; M Tribalto; M Lopez; M T Petrucci; L Fontana
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

5.  Systemic administration of autologous, alloactivated helper-enriched lymphocytes to patients with metastatic melanoma of the lung. A phase I study.

Authors:  A Balsari; R Marolda; C Gambacorti-Passerini; G Sciorelli; G Tona; E Cosulich; D Taramelli; G Fossati; G Parmiani; N Cascinelli
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

Review 6.  The antitumor effects of interferon.

Authors:  I Gresser
Journal:  Med Oncol Tumor Pharmacother       Date:  1986

7.  In vitro modulation of human natural killer cell activity by interferon: generation of adherent suppressor cells.

Authors:  A Uchida; E Yanagawa; E M Kokoschka; M Micksche; H S Koren
Journal:  Br J Cancer       Date:  1984-10       Impact factor: 7.640
  7 in total

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