Literature DB >> 6925979

Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-alpha.

S Einhorn, C Jarstrand.   

Abstract

The influence of daily intramuscular injections of 3 X 10(6) units of interferon-alpha (IFN-alpha) on the phagocytic activity of peripheral monocytes was studied in 28 tumor patients. One day after initiation of IFN therapy no major change in the capacity of monocytes to ingest yeast particles was observed. After 1 week, 3 months, 6 months, and 9 months of treatment, monocyte phagocytosis had decreased in the majority of the patients tested. In patients where natural killer (NK) cell activity was measured simultaneously with monocyte phagocytosis, a correlation between the degree of enhancement of NK activity and the degree of decrease in monocyte phagocytosis was observed.

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Year:  1982        PMID： 6925979     DOI： 10.1007/bf00205379

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  19 in total

1.  Distribution of latex-ingesting cells, T cells, and B cells in the peripheral blood of patients with malignant melanoma.

Authors:  B Koziner; A B Cosimi; K J Bloch
Journal:  J Natl Cancer Inst       Date:  1975-12       Impact factor: 13.506

2.  SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.

Authors:  A S COULSON; D G CHALMERS
Journal:  Lancet       Date:  1964-02-29       Impact factor: 79.321

3.  Phagocytosis-enhancing effect of human leukocyte interferon preparation of human peripheral monocytes in vitro.

Authors:  J Imanishi; Y Yokota; T Kishida; T Mukainaka; A Matsuo
Journal:  Acta Virol       Date:  1975-01       Impact factor: 1.162

4.  Abnormal monocyte chemotactic response in cancer patients.

Authors:  D A Boetcher; E J Leonard
Journal:  J Natl Cancer Inst       Date:  1974-04       Impact factor: 13.506

5.  Interferon and spontaneous cytotoxicity in man. II. Studies in patients receiving exogenous leukocyte interferon.

Authors:  S Einhorn; H Blomgren; H Strander
Journal:  Acta Med Scand       Date:  1978

6.  Lymphokine production by PHA-stimulated human lymphocytes is enhanced by interferon.

Authors:  H Blomgren; S Einhorn
Journal:  Int Arch Allergy Appl Immunol       Date:  1981

Review 7.  Do natural killer cells engage in regulated reactions against self to ensure homeostasis?

Authors:  G Cudkowicz; P S Hochman
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

8.  Interferon in cancer: Faith, hope and reality.

Authors:  H Strander; S Einhorn
Journal:  Am J Clin Oncol       Date:  1982-06       Impact factor: 2.339

9.  Effect of an intramuscular injection of human leukocyte interferon on blood leukocyte counts and proportions of lymphocytes forming E, EA and EAC rosettes.

Authors:  S Einhorn; H Blomgren; H Strander
Journal:  Int Arch Allergy Appl Immunol       Date:  1980

10.  Monocytes and macrophages in malignant melanoma. III. Reduction of nitroblue tetrazolium by peripheral blood monocytes.

Authors:  D W Hedley; G A Currie
Journal:  Br J Cancer       Date:  1978-05       Impact factor: 7.640
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  6 in total

1.  Influence of alpha-interferon therapy on blood lymphoid cells. Studies on antibody production, mixed lymphocyte culture response, mitogen responsiveness and 2'-5'oligoadenylate synthetase activity.

Authors:  S Einhorn; P Ling; N Einhorn; H Strander; J Wasserman
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

2.  Enhancement of defective monocyte function during immunotherapy with recombinant interferon.

Authors:  H Nielsen; P Ernst
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

3.  Influence of human interferon-alpha therapy on cytotoxic functions of blood lymphocytes. Studies on lectin-dependent cellular cytotoxicity, antibody-dependent cellular cytotoxicity, and natural killer cell activity.

Authors:  S Einhorn; H Blomgren; H Strander; J Wasserman
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968

4.  Functions of human neutrophilic granulocytes after in vivo exposure to interferon alpha.

Authors:  S Einhorn; C Jarstrand
Journal:  Infect Immun       Date:  1984-03       Impact factor: 3.441

5.  Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivo.

Authors:  J Rhodes; D H Jones; N M Bleehen
Journal:  Clin Exp Immunol       Date:  1983-09       Impact factor: 4.330

6.  Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide.

Authors:  C F Nathan; C R Horowitz; J de la Harpe; S Vadhan-Raj; S A Sherwin; H F Oettgen; S E Krown
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205
  6 in total

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