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Literature DB >> 3783618

A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.

B Wainwright, M Farrall, E Watson, R Williamson.

Abstract

We have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.

Entities: Disease

Mesh：

Year: 1986 PMID： 3783618 PMCID： PMC1049778 DOI： 10.1136/jmg.23.5.417

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

27 in total

1. Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors: L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal: Proc Natl Acad Sci U S A Date: 1977-03 Impact factor: 11.205

2. Isolation and sequence of a human cytochrome P-450 cDNA clone.

Authors: I R Phillips; E A Shephard; A Ashworth; B R Rabin
Journal: Proc Natl Acad Sci U S A Date: 1985-02 Impact factor: 11.205

3. Possible localisation of the gene for cystic fibrosis of the pancreas to the short arm of chromosome 5.

Authors: D W Smith; J M Docter; P E Ferrier; J L Frias; A Spock
Journal: Lancet Date: 1968-08-10 Impact factor: 79.321

4. Incidence in Italy, genetic heterogeneity, and segregation analysis of cystic fibrosis.

Authors: G Romeo; M Bianco; M Devoto; P Menozzi; G Mastella; A M Giunta; C Micalizzi; M Antonelli; A Battistini; F Santamaria
Journal: Am J Hum Genet Date: 1985-03 Impact factor: 11.025

5. Somatic cell genetic studies of the cystic fibrosis mucociliary inhibitor.

Authors: B J Mayo; R J Klebe; D R Barnett; B J Lankford; B H Bowman
Journal: Clin Genet Date: 1980-11 Impact factor: 4.438

6. Localisation of genetic markers and orientation of the linkage group on chromosome 19.

Authors: J D Brook; D J Shaw; L Meredith; G A Bruns; P S Harper
Journal: Hum Genet Date: 1984 Impact factor: 4.132

7. Linkage studies between polymorphic markers on chromosome 4 and cystic fibrosis.

Authors: P Scambler; T Robbins; C Gilliam; A Boylston; P Tippett; R Williamson; K E Davies
Journal: Hum Genet Date: 1985 Impact factor: 4.132

8. A DNA polymorphism adjacent to the human apolipoprotein CII gene.

Authors: S E Humphries; N I Jowett; L Williams; A Rees; M Vella; A Kessling; O Myklebost; A Lydon; M Seed; D J Galton
Journal: Mol Biol Med Date: 1983-12

9. Cystic fibrosis is not caused by a defect in the gene coding for human complement C3.

Authors: K E Davies; T C Gilliam; R Williamson
Journal: Mol Biol Med Date: 1983-09

10. Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis.

Authors: M Knowles; J Gatzy; R Boucher
Journal: N Engl J Med Date: 1981-12-17 Impact factor: 91.245

8 in total

1. Exclusion of autosomal dominant polycystic kidney disease type II (ADPKD2) from 160 cM of chromosome 1.

Authors: S Kumar; W J Kimberling; P A Gabow; Y Y Shugart; S Pieke-Dahl
Journal: J Med Genet Date: 1990-11 Impact factor: 6.318

2. Localization of the Aland Island eye disease locus to the pericentromeric region of the X chromosome by linkage analysis.

Authors: T Alitalo; T A Kruse; H Forsius; A W Eriksson; A de la Chapelle
Journal: Am J Hum Genet Date: 1991-01 Impact factor: 11.025

3. Localization of the mutation in an extended family with Charcot-Marie-Tooth neuropathy (HMSN I).

Authors: P Raeymaekers; V Timmerman; P De Jonghe; L Swerts; J Gheuens; J J Martin; L Muylle; G De Winter; A Vandenberghe; C Van Broeckhoven
Journal: Am J Hum Genet Date: 1989-12 Impact factor: 11.025

4. Autosomal dominant retinitis pigmentosa: exclusion of the gene from the short arm of chromosome 1 including the region surrounding the rhesus locus.

Authors: D G Bradley; G J Farrar; E M Sharp; P Kenna; M M Humphries; D J McConnell; S P Daiger; P McWilliam; P Humphries
Journal: Am J Hum Genet Date: 1989-04 Impact factor: 11.025

8. An efficient strategy for gene mapping using multipoint linkage analysis: exclusion of the multiple endocrine neoplasia 2A (MEN2A) locus from chromosome 13.

Authors: L A Farrer; P J Goodfellow; C M Lamarche; I Franjkovic; S Myers; B N White; J J Holden; J R Kidd; N E Simpson; K K Kidd
Journal: Am J Hum Genet Date: 1987-04 Impact factor: 11.025