Literature DB >> 6542168

Dihomo-gamma-linolenic acid reverses hypertension induced in rats by diets rich in saturated fat.

C H Hassall, S J Kirtland.   

Abstract

This study has shown that hypertension induced in rats by a diet rich in saturated fat (16% coconut oil, 4% palmitic acid by weight) is reversed by the addition of the essential fatty acid, dihomo-gamma-linolenic acid (DHLA), at 5.0% but not at 0.5% of dietary energy. This potent effect of DHLA has been attributed to modulation of prostaglandin biosynthesis.

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Year:  1984        PMID： 6542168     DOI： 10.1007/bf02534530

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  17 in total

1.  Measurement of blood pressure in unanaesthetized rats and mice.

Authors:  M Gerold; H Tschirky
Journal:  Arzneimittelforschung       Date:  1968-10

2.  Influence of renal prostaglandins and dietary linoleate on hypertension in Dahl S rats.

Authors:  L Tobian; M Ganguli; M A Johnson; J Iwai
Journal:  Hypertension       Date:  1982 May-Jun       Impact factor: 10.190

Review 3.  The biosynthesis of unsaturated fatty acids and its control in mammalian liver.

Authors:  R Jeffcoat
Journal:  Essays Biochem       Date:  1979       Impact factor: 8.000

4.  The role of dietary essential fatty acids and prostaglandins in reducing blood pressure.

Authors:  J M Iacono; J T Judd; M W Marshall; J J Canary; R M Dougherty; J F Mackin; B T Weinland
Journal:  Prog Lipid Res       Date:  1981       Impact factor: 16.195

Review 5.  Possible significance of renal prostaglandins in essential hypertension.

Authors:  P C Weber; W Siess; B Scherer
Journal:  Clin Exp Hypertens       Date:  1980       Impact factor: 1.749

6.  Role of prostaglandins in the control of renin secretion in the dog (II).

Authors:  J C Yun; G D Kelly; F C Bartter; G W Smith
Journal:  Life Sci       Date:  1978-09-04       Impact factor: 5.037

7.  Nutritional and hormonal factors influencing desaturation of essential fatty acids.

Authors:  R R Brenner
Journal:  Prog Lipid Res       Date:  1981       Impact factor: 16.195

8.  The influence of a linoleic acid-rich diet and of acetyl salicylic acid on NaCl induced hypertension, Na+--and H2O-blance and urinary prostaglandin excretion in rats.

Authors:  F ten Hoor; H M van de Graaf
Journal:  Acta Biol Med Ger       Date:  1978

9.  Urinary prostaglandins. Identification and origin.

Authors:  J C Frölich; T W Wilson; B J Sweetman; M Smigel; A S Nies; K Carr; J T Watson; J A Oates
Journal:  J Clin Invest       Date:  1975-04       Impact factor: 14.808

10.  The metabolism of dihomo-gamma-linolenic acid in man.

Authors:  K J Stone; A L Willis; W M Hart; S J Kirtland; P B Kernoff; G P McNicol
Journal:  Lipids       Date:  1979-02       Impact factor: 1.880
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  4 in total

1.  Antibiotic-like action of essential fatty acids.

Authors:  U N Das
Journal:  Can Med Assoc J       Date:  1985-06-15       Impact factor: 8.262

2.  Dietary fatty acids and the risk of hypertension in middle-aged and older women.

Authors:  Lu Wang; Joann E Manson; John P Forman; J Michael Gaziano; Julie E Buring; Howard D Sesso
Journal:  Hypertension       Date:  2010-08-16       Impact factor: 10.190

3.  Dietary N-6 and N-3 fatty acids and salt-induced hypertension in the borderline hypertensive rat.

Authors:  D E Mills; R P Ward; M Mah; L DeVette
Journal:  Lipids       Date:  1989-01       Impact factor: 1.880

4.  Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis.

Authors:  Hayley Gallagher; Jessica O Williams; Nele Ferekidis; Alaa Ismail; Yee-Hung Chan; Daryn R Michael; Irina A Guschina; Victoria J Tyrrell; Valerie B O'Donnell; John L Harwood; Inna Khozin-Goldberg; Sammy Boussiba; Dipak P Ramji
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2019-06-13       Impact factor: 5.187
  4 in total

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