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Literature DB >> 3698059

Distribution of intact and Fab2(1) fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts.

Abstract

A direct comparative study of the distribution of intact and Fab2(1) fragments of mouse monoclonal anti-human chorionic gonadotrophin antibody, W14A, in nude mice bearing a human choriocarcinoma xenograft, indicates that the tumour:blood ratio is generally improved with fragments. Some parameters which may determine the distribution are outlined.

Entities: Disease Species

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Year: 1986 PMID： 3698059 DOI： 10.1007/bf00199363

Source DB: PubMed Journal: Cancer Immunol Immunother ISSN： 0340-7004 Impact factor: 6.968

22 in total

1. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

Review 2. Endocytosis.

Authors: S C Silverstein; R M Steinman; Z A Cohn
Journal: Annu Rev Biochem Date: 1977 Impact factor: 23.643

3. The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model.

Authors: R G Melton; F Searle; R F Sherwood; K D Bagshawe; J A Boden
Journal: Br J Cancer Date: 1990-03 Impact factor: 7.640

3 in total

Distribution of intact and Fab2(1) fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts.

1. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Review 2. Endocytosis.

Review 3. Impaired peripheral conversion of thyroxine to triiodothyronine,.

4. Nature of the subunits of human chorionic gonadotropin.

5. The biological properties of immunoglobulin G and its split products [F(ab')2 and Fab].

6. The kinetics of antibody binding to membrane antigens in solution and at the cell surface.

7. Preparation of covalent IgG complexes of defined size and their clearance from the circulation of mice.

8. Choriocarcinoma scanning using radiolabeled anti-body to chorionic gonadotrophin.

9. Radioimmunodetection of human tumor xenografts by monoclonal antibodies.

10. A human choriocarcinoma xenograft in nude mice; a model for the study of antibody localization.

1. Optimal tumor targeting by antibodies: development of a mathematical model.

2. Changes in leucocyte populations following murine bifunctional antibody infusion in colon cancer patients.

3. The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model.