Literature DB >> 652828

Intoxicating effects of three aliphatic alcohols and barbital on two rat strains genetically selected for their ethanol intake.

A Malila.   

Abstract

Intoxicating effects of ethanol, isopropanol, tert. butanol and barbital were studied by comparing performances on the tilted plane of ethanol preferring AA (Alko, Alcohol) and ethanol avoiding ANA (Alko, Non-Alcohol) rat strains raised by genetic selection for their voluntary ethanol intake. The motor coordination of AA rats was found to be less affected than that of ANA rats by all three alcohols and barbital. The results indicate a marked genetic difference in neural tolerance to the alcohols and barbital, and suggest that neural tolerance to alcohols plays a role in determining the ethanol preference of AA rats and ethanol aversion of ANA rats.

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Year:  1978        PMID： 652828     DOI： 10.1016/0091-3057(78)90337-4

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  14 in total

1.  The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder.

Authors:  David J Rossi; Ben D Richardson
Journal:  Handb Exp Pharmacol       Date:  2018

2.  Effects of acute ethanol on beta-endorphin release in the nucleus accumbens of selectively bred lines of alcohol-preferring AA and alcohol-avoiding ANA rats.

Authors:  Minh P Lam; Harri Nurmi; Noora Rouvinen; Kalervo Kiianmaa; Christina Gianoulakis
Journal:  Psychopharmacology (Berl)       Date:  2009-11-26       Impact factor: 4.530

3.  Factors involved in the differential response to ethanol, barbital and pentobarbital in rats selectively bred for ethanol sensitivity.

Authors:  J M Mayer; J M Khanna; H Kalant; A Chau
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

Review 4.  The AA and ANA rat lines, selected for differences in voluntary alcohol consumption.

Authors:  J D Sinclair; A D Lê; K Kiianmaa
Journal:  Experientia       Date:  1989-09-15

5.  Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms.

Authors:  Ben D Richardson; David J Rossi
Journal:  J Neurophysiol       Date:  2017-04-05       Impact factor: 2.714

6.  Characteristics of ethanol tolerance in alcohol drinking (AA) and alcohol avoiding (ANA) rats.

Authors:  A D Lê; K Kiianmaa
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

7.  The ethanol stimulus in rats with differing ethanol preferences.

Authors:  J L York
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

8.  Differential sensitivity to ethanol, pentobarbital, and barbital in spontaneously hypertensive and normotensive Wistar-Kyoto rats.

Authors:  J M Khanna; A D Lê; H Kalant; C Kim
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

9.  Fixed-ratio schedules of oral ethanol self-administration in inbred mouse strains.

Authors:  G I Elmer; R A Meisch; S R Goldberg; F R George
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

10.  Alcohol Suppresses Tonic GABAA Receptor Currents in Cerebellar Granule Cells in the Prairie Vole: A Neural Signature of High-Alcohol-Consuming Genotypes.

Authors:  Joshua S Kaplan; Claudia Mohr; Caroline M Hostetler; Andrey E Ryabinin; Deborah A Finn; David J Rossi
Journal:  Alcohol Clin Exp Res       Date:  2016-07-18       Impact factor: 3.455
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