Literature DB >> 6525171

The intracellular calcium antagonist TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] inhibits mitochondrial ATP production in rat thymocytes.

M D Brand, S M Felber.   

Abstract

TMB-8 inhibited respiration of rat thymocytes and rat liver mitochondria, probably by inhibition of NADH dehydrogenase. TMB-8 markedly decreased both the cellular ATP concentration and the mitochondrial membrane potential in situ in thymocytes. These effects occurred at, or well below, the concentrations used in other systems to investigate the role of intracellular calcium pools in signalling events. We conclude that caution should be exercised in the interpretation of the effects of TMB-8.

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Year:  1984        PMID： 6525171      PMCID： PMC1144544          DOI： 10.1042/bj2241027

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

1.  Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction.

Authors:  R R Gorman; W Wierenga; O V Miller
Journal:  Biochim Biophys Acta       Date:  1979-01-29

2.  The activation by Ca2+ of platelet phospholipase A2. Effects of dibutyryl cyclic adenosine monophosphate and 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate.

Authors:  S Rittenhouse-Simmons; D Deykin
Journal:  Biochim Biophys Acta       Date:  1978-11-01

3.  Mitogens and melittin stimulate an increase in intracellular free calcium concentration in human fibroblasts.

Authors:  L L Mix; R J Dinerstein; M L Villereal
Journal:  Biochem Biophys Res Commun       Date:  1984-02-29       Impact factor: 3.575

4.  Inhibition of platelet secretion by an antagonist of intracellular calcium.

Authors:  I F Charo; R D Feinman; T C Detwiler
Journal:  Biochem Biophys Res Commun       Date:  1976-10-18       Impact factor: 3.575

5.  The isolation of lymphocyte mitochondria and their regulation of extramitochondrial free Ca2+ concentration.

Authors:  N G Dippenaar; M D Brand
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857

6.  The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human neutrophils.

Authors:  J E Smolen; H M Korchak; G Weissmann
Journal:  Biochim Biophys Acta       Date:  1981-11-05

Review 7.  Mitochondrial calcium transport.

Authors:  D Nicholls; K Akerman
Journal:  Biochim Biophys Acta       Date:  1982-09-01

Review 8.  Mechanisms of action of membrane calcium channel blockers and intracellular calcium antagonists.

Authors:  R G Rahwan
Journal:  Med Res Rev       Date:  1983 Jan-Mar       Impact factor: 12.944

9.  Valinomycin can depolarize mitochondria in intact lymphocytes without increasing plasma membrane potassium fluxes.

Authors:  S M Felber; M D Brand
Journal:  FEBS Lett       Date:  1982-12-13       Impact factor: 4.124

10.  Pharmacological evaluation of a new Ca2+ antagonist, 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles.

Authors:  M H Malagodi; C Y Chiou
Journal:  Eur J Pharmacol       Date:  1974-06       Impact factor: 4.432
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  12 in total

1.  8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB-8) acts as a muscarinic receptor antagonist in the epithelial cell line HT29.

Authors:  J Leipziger; J Thomas; P Rubini-Illes; R Nitschke; R Greger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-02       Impact factor: 3.000

2.  Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements.

Authors:  Shona A Mookerjee; Akos A Gerencser; David G Nicholls; Martin D Brand
Journal:  J Biol Chem       Date:  2017-03-07       Impact factor: 5.157

3.  The abnormal-shaped mitochondria in thymus lymphocytes treated with inhibitors of mitochondrial energetics.

Authors:  O V Markova; E N Mokhova; A N Tarakanova
Journal:  J Bioenerg Biomembr       Date:  1990-02       Impact factor: 2.945

4.  The inhibition of alpha 1-adrenoceptor-mediated contractions of rabbit pulmonary artery by Ca2+-withdrawal, pertussis toxin and N-ethylmaleimide is dependent on agonist intrinsic efficacy.

Authors:  S Liebau; J Hohlfeld; U Förstermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-05       Impact factor: 3.000

5.  Effect of TMB-8 on calcium transport in mast cells in relation to histamine secretion.

Authors:  N Chakravarty
Journal:  Agents Actions       Date:  1988-04

6.  Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells.

Authors:  A Lückhoff; U Pohl; A Mülsch; R Busse
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

7.  Effects of inositol trisphosphate on calcium mobilization in bone cells.

Authors:  R Falsafi; D N Tatakis; S Hagel-Bradway; R Dziak
Journal:  Calcif Tissue Int       Date:  1991-11       Impact factor: 4.333

8.  Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake.

Authors:  F B Palmer; D M Byers; M W Spence; H W Cook
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

9.  Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane.

Authors:  Adrian J Lambert; Martin D Brand
Journal:  Biochem J       Date:  2004-09-01       Impact factor: 3.857

10.  Role of Ca2+ and calmodulin in ehrlichial infection in macrophages.

Authors:  Y Rikihisa; Y Zhang; J Park
Journal:  Infect Immun       Date:  1995-06       Impact factor: 3.441
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