Literature DB >> 6704133

Mitogens and melittin stimulate an increase in intracellular free calcium concentration in human fibroblasts.

L L Mix, R J Dinerstein, M L Villereal.   

Abstract

Intracellular free Ca+2 concentration was measured in cultured human fibroblasts (HSWP) utilizing the Ca+2-sensitive fluorescent probe quin2. The addition of peptide growth factors to serum-deprived HSWP cells induced an immediate rise in intracellular Ca+2 concentration. This mitogen-induced rise in Ca+2 concentration could be blocked by the addition of the intracellular Ca+2 antagonist TMB-8. Addition of the phospholipase activator, melittin, to cells in the absence of growth factors also caused a dramatic rise in intracellular Ca+2 concentration which was blocked by TMB-8.

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Year:  1984        PMID： 6704133     DOI： 10.1016/0006-291x(84)91619-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

1.  Ca(2+)-independent form of protein kinase C may regulate Na+ transport across frog skin.

Authors:  M M Civan; A Oler; K Peterson-Yantorno; K George; T G O'Brien
Journal:  J Membr Biol       Date:  1991-04       Impact factor: 1.843

2.  Diacylglycerol downregulates junctional membrane permeability. TMB-8 blocks this effect.

Authors:  T Yada; B Rose; W R Loewenstein
Journal:  J Membr Biol       Date:  1985       Impact factor: 1.843

3.  The intracellular calcium antagonist TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] inhibits mitochondrial ATP production in rat thymocytes.

Authors:  M D Brand; S M Felber
Journal:  Biochem J       Date:  1984-12-15       Impact factor: 3.857

4.  Downregulation of cell-to-cell communication by the viral src gene is blocked by TMB-8 and recovery of communication is blocked by vanadate.

Authors:  B Rose; T Yada; W R Loewenstein
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

5.  Effect of changes of pHi on intracellular calcium in a smooth muscle-like cell line.

Authors:  R W Putnam; P B Douglas
Journal:  Mol Cell Biochem       Date:  1990-12-20       Impact factor: 3.396

6.  Bradykinin causes a transient rise of intracellular Ca2+-activity in cultured neural cells.

Authors:  G Reiser; B Hamprecht
Journal:  Pflugers Arch       Date:  1985-10       Impact factor: 3.657

7.  Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

Authors:  J V Bonventre; M Swidler
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808

8.  Dual Ca2+ requirement for optimal lipid peroxidation of low density lipoprotein by activated human monocytes.

Authors:  Q Li; A Tallant; M K Cathcart
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

9.  Activation of Na+/H+ exchange in cultured fibroblasts: synergism and antagonism between phorbol ester, Ca2+ ionophore, and growth factors.

Authors:  L M Vicentini; M L Villereal
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

10.  Protection of rat atrial myocardium against electrical, mechanical and structural aspects of injury caused by exposure in vitro to conditions of simulated ischaemia.

Authors:  A M Northover; B J Northover
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739
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