Literature DB >> 6517742

Gamma-carboxyglutamate in normal and pathological human middle ear bones.

G Zajic, M D Graham, J Schacht.   

Abstract

The presence of the amino acid gamma-carboxyglutamate (GLA) was established in human middle ear bones. Proteins containing GLA have been described as being associated with normal as well as pathological calcifications. The GLA content of human incus, malleus, and stapes with 1-2 nmol/mg bone is in the range previously reported for a variety of bone. A limited number of samples with middle ear pathology, including otosclerosis, did not show altered GLA levels.

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Year:  1984        PMID： 6517742     DOI： 10.1007/bf00457917

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  12 in total

1.  Incorporation of radioactive calcium into otolithic membranes and middle ear ossicles of the gerbil.

Authors:  R E Preston; L G Johnsson; J H Hill; J Schacht
Journal:  Acta Otolaryngol       Date:  1975 Sep-Oct       Impact factor: 1.494

2.  Characterization of a gamma-carboxyglutamic acid-containing protein from bone.

Authors:  P A Price; A A Otsuka; J W Poser; J Kristaponis; N Raman
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

3.  Quantitative determination of gamma-carboxyglutamic acid in proteins.

Authors:  P V Hauschka
Journal:  Anal Biochem       Date:  1977-05-15       Impact factor: 3.365

4.  A method for decarboxylation of gamma-carboxyglutamic acid in proteins. Properties of the decarboxylated gamma-carboxyglutamic acid protein from calf bone.

Authors:  J W Poser; P A Price
Journal:  J Biol Chem       Date:  1979-01-25       Impact factor: 5.157

5.  The mode of action of vitamin K. Identification of gamma-carboxyglutamic acid as a component of prothrombin.

Authors:  G L Nelsestuen; T H Zytkovicz; J B Howard
Journal:  J Biol Chem       Date:  1974-10-10       Impact factor: 5.157

6.  Assay of gamma-carboxyglutamate in tissue and body fluid by selective hydrolysis and amino acid analysis.

Authors:  Y Ishikawa; R E Wuthier
Journal:  Anal Biochem       Date:  1981-07-01       Impact factor: 3.365

7.  Incorporation of radioactive calcium into otolithic membranes of the guinea pig after aminoglycoside treatment.

Authors:  I Mechigian; R E Preston; L G Johnsson; J Schacht
Journal:  Acta Otolaryngol       Date:  1979       Impact factor: 1.494

8.  Vitamin K dependent modifications of glutamic acid residues in prothrombin.

Authors:  J Stenflo; P Fernlund; W Egan; P Roepstorff
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

9.  Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue.

Authors:  P V Hauschka; J B Lian; P M Gallop
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

10.  Properties and biosynthesis of a vitamin K-dependent calcium binding protein in bone.

Authors:  J B Lian; P V Hauschka; P M Gallop
Journal:  Fed Proc       Date:  1978-10
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  1 in total

1.  Prognostic implications of an undetectable ultrasensitive prostate-specific antigen level after radical prostatectomy.

Authors:  Michael L Eisenberg; Benjamin J Davies; Matthew R Cooperberg; Janet E Cowan; Peter R Carroll
Journal:  Eur Urol       Date:  2009-04-03       Impact factor: 20.096
  1 in total

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