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Literature DB >> 6510464

Model-independent assessment of accumulation kinetics based on moments of drug disposition curves.

Abstract

The bounds of the accumulation profile can be predicted on the basis of the mean disposition residence time (MDRT) of a drug. The time to reach 90% of the plateau level (t0.9) is less than 3.7 MDRT. This prediction can be improved if, in addition, the variance of disposition residence time (VDRT, CV2D = VDRT/MDRT2), or the terminal exponential coefficient (lambda), is known. For CV2D----1 or lambda MDRT----1, the time to reach steady state (t0.9) approaches 2.3 MDRT (limiting case of monoexponential drug disposition curve). Conditions are stated under which lambda can be regarded as the principal determinant of the accumulation rate.

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Year: 1984 PMID： 6510464 DOI： 10.1007/bf00542175

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

8 in total

1. Pharmacokinetics of digoxin: relationship between response intensity and predicted compartmental drug levels in man.

Authors: W G Kramer; A J Kolibash; R P Lewis; M S Bathala; J A Visconti; R H Reuning
Journal: J Pharmacokinet Biopharm Date: 1979-02

2. Rapid compartment- and model-independent estimation of times required to attain various fractions of steady-state plasma level during multiple dosing of drugs obeying superposition principle and having various absorption or infusion kinetics.

Authors: W L Chiou
Journal: J Pharm Sci Date: 1979-12 Impact factor: 3.534

8. Compartment- and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion.

Authors: W L Chiou
Journal: J Pharmacokinet Biopharm Date: 1980-06

8 in total

3 in total

1. The relevance of residence time theory to pharmacokinetics.

Authors: M Weiss
Journal: Eur J Clin Pharmacol Date: 1992 Impact factor: 2.953

Review 2. Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).

Authors: P Veng-Pedersen
Journal: Clin Pharmacokinet Date: 1989-12 Impact factor: 6.447

3. Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. I. Log-convex drug disposition curves.

Authors: M Weiss
Journal: J Pharmacokinet Biopharm Date: 1986-12

3 in total

Model-independent assessment of accumulation kinetics based on moments of drug disposition curves.

1. Pharmacokinetics of digoxin: relationship between response intensity and predicted compartmental drug levels in man.

2. Rapid compartment- and model-independent estimation of times required to attain various fractions of steady-state plasma level during multiple dosing of drugs obeying superposition principle and having various absorption or infusion kinetics.

3. Use of gamma distributed residence times in pharmacokinetics.

4. Hemodynamic influences upon the variance of disposition residence time distribution of drugs.

5. A standard approach to compiling clinical pharmacokinetic data.

6. Statistical moments in pharmacokinetics.

7. Residence time and accumulation of drugs in the body.

8. Compartment- and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion.

1. The relevance of residence time theory to pharmacokinetics.

Review 2. Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).

3. Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. I. Log-convex drug disposition curves.