Literature DB >> 6492998

Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species.

D S Duch, S W Bowers, J H Woolf, C A Nichol.   

Abstract

Levels of GTP cyclohydrolase, neopterin and biopterin were determined in tissues and body fluids of humans, monkey, dog and mouse. Highest levels of GTP cyclohydrolase and biopterin were found in pineal, liver, spleen, bone marrow, whole adrenal gland and small intestine. High levels of biopterin were found in the urine of all species examined. High levels of neopterin were found only in the urine of humans and monkeys, very low levels could be detected in dog, while none could be detected in mouse, rat, guinea pig or hamster urine.

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Year:  1984        PMID： 6492998     DOI： 10.1016/0024-3205(84)90541-1

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  17 in total

1.  Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts.

Authors:  C Bencsics; S R Wachtel; S Milstien; K Hatakeyama; J B Becker; U J Kang
Journal:  J Neurosci       Date:  1996-07-15       Impact factor: 6.167

2.  Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.

Authors:  Ian Cook; Ting Wang; Thomas S Leyh
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-19       Impact factor: 11.205

3.  Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function.

Authors:  Angus Lindsay; Alexandra Schmiechen; Christopher M Chamberlain; James M Ervasti; Dawn A Lowe
Journal:  Exp Physiol       Date:  2018-07       Impact factor: 2.969

4.  Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.

Authors:  E R Werner; G Werner-Felmayer; D Fuchs; A Hausen; G Reibnegger; H Wachter
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

5.  The effect of age on tetrahydrobiopterin metabolism in the human brain.

Authors:  J Anderson; J A Blair; R A Armstrong
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-02       Impact factor: 10.154

6.  Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin.

Authors:  Tongrong He; Leslie A Smith; Tong Lu; Michael J Joyner; Zvonimir S Katusic
Journal:  Hypertension       Date:  2011-06-27       Impact factor: 10.190

Review 7.  Tetrahydrobiopterin, superoxide, and vascular dysfunction.

Authors:  Jeannette Vásquez-Vivar
Journal:  Free Radic Biol Med       Date:  2009-07-21       Impact factor: 7.376

8.  Impact of tumour necrosis factor-alpha and interferon-gamma on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages.

Authors:  E R Werner; G Werner-Felmayer; D Fuchs; A Hausen; G Reibnegger; J J Yim; H Wachter
Journal:  Biochem J       Date:  1991-12-15       Impact factor: 3.857

9.  The fate of intravenously administered tetrahydrobiopterin and its implications for heterologous gene therapy of phenylketonuria.

Authors:  Cary O Harding; Mark Neff; Krzysztof Wild; Kelly Jones; Lina Elzaouk; Beat Thöny; Sheldon Milstien
Journal:  Mol Genet Metab       Date:  2004-01       Impact factor: 4.797

10.  Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia.

Authors:  Tetsuaki Hashiguchi; Yasuyuki Kakihana; Sumikazu Isowaki; Tamotsu Kuniyoshi; Tatsuya Kaminosono; Etsuro Nagata; Kazumi Tobo; Masamichi Tahara; Naoko Okayama; Yuki Arakawa; Yoshie Kakihara; Tsuyoshi Goromaru; Nobuo Nakanishi; Hiroe Nakazawa; Yuichi Kanmura
Journal:  J Anesth       Date:  2008-08-07       Impact factor: 2.078
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