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Literature DB >> 6487504

Cimetidine does not alter ibuprofen kinetics after a single dose.

Abstract

Cimetidine does not slow the disappearance of ibuprofen from the serum after a single dose in healthy male volunteers. This suggests that no change in ibuprofen dosing is necessary when cimetidine is co-administered.

Entities: Chemical

Mesh：

Substances：
Cimetidine
Ibuprofen

Year: 1984 PMID： 6487504 PMCID： PMC1463611 DOI： 10.1111/j.1365-2125.1984.tb02516.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

8 in total

1. The metabolism of ibuprofen.

Authors: R F Mills; S S Adams; E E Cliffe; W Dickinson; J S Nicholson
Journal: Xenobiotica Date: 1973-09 Impact factor: 1.908

2. High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids.

Authors: G F Lockwood; J G Wagner
Journal: J Chromatogr Date: 1982-11-12

3. Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine.

Authors: N S Mann; A J Sachdev
Journal: South Med J Date: 1977-05 Impact factor: 0.954

4. Cimetidine does not alter morphine disposition in man.

Authors: P Mojaverian; I L Fedder; P H Vlasses; H H Rotmensch; M L Rocci; B N Swanson; R K Ferguson
Journal: Br J Clin Pharmacol Date: 1982-12 Impact factor: 4.335

Review 5. Review of cimetidine drug interactions.

Authors: E M Sorkin; D L Darvey
Journal: Drug Intell Clin Pharm Date: 1983-02

6. Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships.

Authors: G F Lockwood; K S Albert; W R Gillespie; G G Bole; T M Harkcom; G J Szpunar; J G Wagner
Journal: Clin Pharmacol Ther Date: 1983-07 Impact factor: 6.875

7. Reduction of liver blood flow and propranolol metabolism by cimetidine.

Authors: J Feely; G R Wilkinson; A J Wood
Journal: N Engl J Med Date: 1981-03-19 Impact factor: 91.245

8. Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion.

Authors: J C O'Laughlin; G R Silvoso; K J Ivey
Journal: Arch Intern Med Date: 1981-05

8 in total

10 in total

Review 1. Interactions between non-steroidal anti-inflammatory drugs and H2-receptor antagonists or prostaglandin analogues.

Authors: J S Dixon; M C Page
Journal: Rheumatol Int Date: 1991 Impact factor: 2.631

Cimetidine does not alter ibuprofen kinetics after a single dose.

1. The metabolism of ibuprofen.

2. High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids.

3. Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine.

4. Cimetidine does not alter morphine disposition in man.

Review 5. Review of cimetidine drug interactions.

6. Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships.

7. Reduction of liver blood flow and propranolol metabolism by cimetidine.

8. Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion.

Review 1. Interactions between non-steroidal anti-inflammatory drugs and H2-receptor antagonists or prostaglandin analogues.

Review 2. Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).

Review 3. Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs.

4. Lack of efficacy of cimetidine and ranitidine as inhibitors of tolbutamide metabolism.

Review 5. Clinical pharmacokinetics of ibuprofen. The first 30 years.

Review 6. Clinical pharmacokinetics of drugs used in juvenile arthritis.

Review 7. Pharmacokinetic interactions of cimetidine 1987.

Review 8. Pharmacokinetics of Ibuprofen in children with cystic fibrosis.

9. Lack of effect of cimetidine on the pharmacokinetics of R(-)- and S(+)-ibuprofen.

10. The consequences of H2 receptor antagonist--piroxicam coadministration in patients with joint disorders.