Literature DB >> 6861443

Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships.

G F Lockwood, K S Albert, W R Gillespie, G G Bole, T M Harkcom, G J Szpunar, J G Wagner.   

Abstract

Ibuprofen kinetics were studied in 15 subjects after four oral doses. Plasma levels of both total and free ibuprofen were measured for 12 hr, and urine was collected for 48 hr after the doses. All subjects showed a nonlinear relationship between dose and total ibuprofen plasma AUC. Free ibuprofen plasma AUC, however, was linearly related to the dose, suggesting that oral clearance based on free drug was dose independent. Urinary recovery data indicated that efficiency of absorption was dose independent.

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Year:  1983        PMID： 6861443     DOI： 10.1038/clpt.1983.136

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  25 in total

1.  Stepwise determination of multicompartment disposition and absorption parameters from extravascular concentration-time data. Application to mesoridazine, flurbiprofen, flunarizine, labetalol, and diazepam.

Authors:  J G Wagner; D A Ganes; K K Midha; I Gonzalez-Younes; J C Sackellares; L D Olson; M B Affrime; J E Patrick
Journal:  J Pharmacokinet Biopharm       Date:  1991-08

2.  Aspirin as a COX inhibitor and anti-inflammatory drug in human skeletal muscle.

Authors:  Stephen M Ratchford; Kaleen M Lavin; Ryan K Perkins; Bozena Jemiolo; Scott W Trappe; Todd A Trappe
Journal:  J Appl Physiol (1985)       Date:  2017-07-13

3.  Controlled release gel of ibuprofen and lidocaine in epidural use--analgesia and systemic absorption in pigs.

Authors:  A Paavola; P Tarkkila; M Xu; T Wahlström; J Yliruusi; P Rosenberg
Journal:  Pharm Res       Date:  1998-03       Impact factor: 4.200

4.  Lack of efficacy of cimetidine and ranitidine as inhibitors of tolbutamide metabolism.

Authors:  G I Adebayo; H A Coker
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

5.  Stereoselective drug disposition: potential for misinterpretation of drug disposition data.

Authors:  A M Evans; R L Nation; L N Sansom; F Bochner; A A Somogyi
Journal:  Br J Clin Pharmacol       Date:  1988-12       Impact factor: 4.335

6.  Stereoselective systemic disposition of ibuprofen enantiomers in the dog.

Authors:  H Y Ahn; G L Amidon; D E Smith
Journal:  Pharm Res       Date:  1991-09       Impact factor: 4.200

7.  Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis.

Authors:  G Geisslinger; K P Stock; D Loew; G L Bach; K Brune
Journal:  Br J Clin Pharmacol       Date:  1993-06       Impact factor: 4.335

8.  Stereoselective, competitive, and nonlinear plasma protein binding of ibuprofen enantiomers as determined in vivo in healthy subjects.

Authors:  J K Paliwal; D E Smith; S R Cox; R R Berardi; V A Dunn-Kucharski; G H Elta
Journal:  J Pharmacokinet Biopharm       Date:  1993-04

9.  Population pharmacokinetics of high dose ibuprofen in cystic fibrosis.

Authors:  I Arranz; A Martín-Suárez; J M Lanao; F Mora; C Vázquez; A Escribano; M Juste; J Mercader; E Ripoll
Journal:  Arch Dis Child       Date:  2003-12       Impact factor: 3.791

10.  Use of stable isotopes for evaluation of drug delivery systems: comparison of ibuprofen release in vivo and in vitro from two biphasic release formulations utilizing different rate-controlling polymers.

Authors:  D L Theis; L J Lucisano; G W Halstead
Journal:  Pharm Res       Date:  1994-08       Impact factor: 4.200
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