Literature DB >> 7153281

High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids.

G F Lockwood, J G Wagner.   

Abstract

A sensitive and selective high-performance liquid-chromatographic assay for ibuprofen and its major metabolites in biological fluids is described. To ensure good chromatographic separation the drug and metabolites were run on a gradient elution system and detected with a variable wavelength detector set at 220 nm. A second, more rapid, isocratic system is also described for the detection of only ibuprofen.

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Year:  1982        PMID: 7153281     DOI: 10.1016/s0378-4347(00)84173-0

Source DB:  PubMed          Journal:  J Chromatogr


  15 in total

1.  Biopharmaceutical evaluation of ibufenac, ibuprofen, and their hydroxyethoxy analogs in the rabbit eye.

Authors:  C S Rao; R D Schoenwald; C F Barfknecht; S L Laban
Journal:  J Pharmacokinet Biopharm       Date:  1992-08

2.  The effect of magnesium hydroxide on the oral absorption of ibuprofen, ketoprofen and diclofenac.

Authors:  P J Neuvonen
Journal:  Br J Clin Pharmacol       Date:  1991-03       Impact factor: 4.335

3.  Pharmacokinetics of ibuprofen in man--III: Plasma protein binding.

Authors:  G F Lockwood; K S Albert; G J Szpunar; J G Wagner
Journal:  J Pharmacokinet Biopharm       Date:  1983-10

4.  Pharmacokinetics of ibuprofen in man IV: absorption and disposition.

Authors:  J G Wagner; K S Albert; G J Szpunar; G F Lockwood
Journal:  J Pharmacokinet Biopharm       Date:  1984-08

5.  Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans.

Authors:  D J Carlile; N Hakooz; M K Bayliss; J B Houston
Journal:  Br J Clin Pharmacol       Date:  1999-06       Impact factor: 4.335

6.  Pharmacokinetics and metabolism of 14C isobytylnaphtyl acetic acid in rat.

Authors:  C Jacquot; E Payan-Lepain; M O Christen; G Achtert; H J Hausleiter; F Borchers
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Oct-Dec       Impact factor: 2.441

7.  The effect of food on gastrointestinal (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy.

Authors:  M T Borin; S Khare; R M Beihn; M Jay
Journal:  Pharm Res       Date:  1990-03       Impact factor: 4.200

8.  Stereoselective disposition of ibuprofen enantiomers in the isolated perfused rat kidney.

Authors:  H Y Ahn; F Jamali; S R Cox; D Kittayanond; D E Smith
Journal:  Pharm Res       Date:  1991-12       Impact factor: 4.200

9.  Cimetidine does not alter ibuprofen kinetics after a single dose.

Authors:  K A Conrad; M Mayersohn; M Bliss
Journal:  Br J Clin Pharmacol       Date:  1984-10       Impact factor: 4.335

10.  Stereoselective disposition of ibuprofen enantiomers in man.

Authors:  E J Lee; K Williams; R Day; G Graham; D Champion
Journal:  Br J Clin Pharmacol       Date:  1985-05       Impact factor: 4.335

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