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Literature DB >> 6476813

Antimicrobial spectrum of Win 49375.

Abstract

Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375 had moderate activity against clostridia but little against Bacteroides fragilis. The drug showed a marked inoculum effect at 10(8) CFU/ml and a slight decrease in potency at pH 5.

Entities: Chemical Species

Mesh：

Substances：

Year: 1984 PMID： 6476813 PMCID： PMC179928 DOI： 10.1128/AAC.26.1.104

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

4 in total

1. Susceptibility of anaerobes to cefoxitin and other cephalosporins.

Authors: F P Tally; N V Jacobus; J G Bartlett; S L Gorbach
Journal: Antimicrob Agents Chemother Date: 1975-02 Impact factor: 5.191

2. In vitro activity of norfloxacin in urine compared to that of cinnoxacin, nalidixic acid and pipemidic acid.

Authors: P M Shah; M Ottrad; W Stille
Journal: Eur J Clin Microbiol Date: 1983-06 Impact factor: 3.267

3. beta-Lactamase activity in human pus.

Authors: R E Bryant; A L Rashad; J A Mazza; D Hammond
Journal: J Infect Dis Date: 1980-10 Impact factor: 5.226

4. In vitro activity of azthreonam, a monobactam antibiotic.

Authors: N V Jacobus; M C Ferreira; M Barza
Journal: Antimicrob Agents Chemother Date: 1982-11 Impact factor: 5.191

4 in total

9 in total

1. The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro.

Authors: J S Wolfson; D C Hooper
Journal: Antimicrob Agents Chemother Date: 1985-10 Impact factor: 5.191

2. In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus.

Authors: S M Smith
Journal: Antimicrob Agents Chemother Date: 1986-02 Impact factor: 5.191

3. Randomized prospective study comparing moxalactam and cefoxitin with or without tobramycin for the treatment of serious surgical infections.

Authors: F P Tally; J M Kellum; J L Ho; T F O'Donnell; M Barza; S L Gorbach
Journal: Antimicrob Agents Chemother Date: 1986-02 Impact factor: 5.191

4. In vitro activity of amifloxacin against outer membrane mutants of the family Enterobacteriaceae and frequency of spontaneous resistance.

Authors: M Watanabe; M Inoue; S Mitsuhashi
Journal: Antimicrob Agents Chemother Date: 1989-11 Impact factor: 5.191

5. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.

Authors: H Thadepalli; S V Gollapudi; S K Chuah
Journal: Antimicrob Agents Chemother Date: 1986-10 Impact factor: 5.191

9. Comparison of in vitro activity of quinolone antibiotics and vancomycin against gentamicin- and methicillin-resistant Staphylococcus aureus by time-kill kinetic studies.

Authors: J K Foster; J R Lentino; R Strodtman; C DiVincenzo
Journal: Antimicrob Agents Chemother Date: 1986-12 Impact factor: 5.191