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Literature DB >> 3539011

Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.

Abstract

Difloxacin (A-56619) and A-56620, two novel fluoroquinolones, were tested in comparison with ciprofloxacin, cefoxitin, and combined clindamycin and gentamicin in the treatment of experimentally induced intraabdominal abscess associated with Bacteroides fragilis. Difloxacin was found to be as effective as clindamycin-gentamicin. A-56620, despite achieving subtherapeutic levels in serum, was found to be as effective as cefoxitin. Both difloxacin and A-56620 were effective in vivo against experimentally induced intra-abdominal abscess in rats.

Entities: Chemical Disease Species

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Year: 1986 PMID： 3539011 PMCID： PMC176483 DOI： 10.1128/AAC.30.4.574

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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6. In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.

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Journal: Antimicrob Agents Chemother Date: 1986-02 Impact factor: 5.191

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Authors: W M Weinstein; A B Onderdonk; J G Bartlett; S L Gorbach
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Journal: Antimicrob Agents Chemother Date: 1982-04 Impact factor: 5.191

7 in total

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Authors: S V Gollapudi; S K Chuah; T Harvey; H D Thadepalli; H Thadepalli
Journal: Antimicrob Agents Chemother Date: 1993-08 Impact factor: 5.191

2. In vivo efficacy of trovafloxacin (CP-99,217), a new quinolone, in experimental intra-abdominal abscesses caused by Bacteroides fragilis and Escherichia coli.

Authors: H Thadepalli; U Reddy; S K Chuah; F Thadepalli; C Malilay; R J Polzer; N Hanna; A Esfandiari; P Brown; S Gollapudi
Journal: Antimicrob Agents Chemother Date: 1997-03 Impact factor: 5.191