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Literature DB >> 6462920

Increased G + C content of DNA stabilizes methyl CpG dinucleotides.

Abstract

The vertebrate genome is a mosaic of regions differing dramatically in their G + C content. Those regions with a high G + C content contain the expected number of CpG dinucleotides and we propose that following methylation these have been protected from deamination by the increased stability of the surrounding DNA duplex. This argument applies both to the microenvironment of the CpG dinucleotide and to whole gene regions.

Entities: Chemical

Mesh：

Substances：
Codon
Globins
DNA

Year: 1984 PMID： 6462920 PMCID： PMC320037 DOI： 10.1093/nar/12.14.5869

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

13 in total

1. Distribution of 5-methylcytosine in pyrimidine sequences of deoxyribonucleic acids.

Authors: J DOSKOCIL; F SORM
Journal: Biochim Biophys Acta Date: 1962-06-11

2. Doublet frequency analysis of fractionated vertebrate nuclear DNA.

Authors: G J Russell; P M Walker; R A Elton; J H Subak-Sharpe
Journal: J Mol Biol Date: 1976-11 Impact factor: 5.469

3. Fluctuational opening of the double helix as revealed by theoretical and experimental study of DNA interaction with formaldehyde.

Authors: A V Lukashin; A V Vologodskii; M D Frank-Kamenetskii; Y L Lyubchenko
Journal: J Mol Biol Date: 1976-12-25 Impact factor: 5.469

4. Globin mRNA sequences: analysis of base pairing and evolutionary implications.

Authors: W Salser
Journal: Cold Spring Harb Symp Quant Biol Date: 1978

5. Conversion of exposed cytidine residues to uridine residues in Escherichia coli formylmethionine transfer ribonucleic acid.

Authors: J P Goddard; L H Schulman
Journal: J Biol Chem Date: 1972-06-25 Impact factor: 5.157

8. Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene.

Authors: A P Bird; M H Taggart; R D Nicholls; D R Higgs
Journal: EMBO J Date: 1987-04 Impact factor: 11.598

8 in total

Increased G + C content of DNA stabilizes methyl CpG dinucleotides.

1. Distribution of 5-methylcytosine in pyrimidine sequences of deoxyribonucleic acids.

2. Doublet frequency analysis of fractionated vertebrate nuclear DNA.

3. Fluctuational opening of the double helix as revealed by theoretical and experimental study of DNA interaction with formaldehyde.

4. Globin mRNA sequences: analysis of base pairing and evolutionary implications.

5. Conversion of exposed cytidine residues to uridine residues in Escherichia coli formylmethionine transfer ribonucleic acid.

6. Nucleic acid reactivity and conformation. II. Reaction of cytosine and uracil with sodium bisulfite.

7. Unmethylated domains in vertebrate DNA.

8. Endonuclease V of Escherichia coli.

9. DNA methylation and the frequency of CpG in animal DNA.

10. Asymmetrical distribution of CpG in an 'average' mammalian gene.

1. Absence of methylation at HpaII sites in three human genomic tRNA sequences.

2. Cytosine Methylation Affects the Mutability of Neighboring Nucleotides in Germline and Soma.

Review 3. DNA methylation. The effect of minor bases on DNA-protein interactions.

4. The distribution of the dinucleotide CpG and cytosine methylation in the vitellogenin gene family.

5. Long range genome structure around the human alpha-globin complex analysed by PFGE.

6. Analysis of CpG suppression in methylated and nonmethylated species.

7. Cytosine methylation and the fate of CpG dinucleotides in vertebrate genomes.

8. Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene.