Literature DB >> 6461858

Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors.

E C LeRoy, S Mercurio, G K Sherer.   

Abstract

To explore the mechanism of increased collagen synthesis by scleroderma skin fibroblasts in vitro, control and scleroderma fibroblasts were compared in confluent monolayer cultures growth-arrested by serum deprivation; responses to optimal mitogenic doses of platelet-derived growth factor, fibroblast growth factor, epidermal growth factor and nerve growth factor were compared. Platelet-derived growth factor had a selective mitogenic effect on control skin fibroblasts not observed with scleroderma skin fibroblasts. None of the factors studied had a selective effect on collagen synthesis independent of cell replication; scleroderma and control fibroblasts responded similarly. Therefore, the growth factors studied may not be involved in generating the activated scleroderma fibroblast directly; platelet-derived growth factor may play an indirect role in fibroblast replication in human fibrotic disorders.U

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Year:  1982        PMID： 6461858      PMCID： PMC345947          DOI： 10.1073/pnas.79.4.1286

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Letters: Fibroblasts from a patient with scleroderma reveal abnormal metabolism.

Authors:  T Krieg; P K Müller; G Goerz
Journal:  Arch Dermatol Res       Date:  1977-07-21       Impact factor: 3.017

2.  Lymphokine stimulation of collagen accumulation.

Authors:  R L Johnson; M Ziff
Journal:  J Clin Invest       Date:  1976-07       Impact factor: 14.808

3.  Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.

Authors:  B Peterkofsky; R Diegelmann
Journal:  Biochemistry       Date:  1971-03-16       Impact factor: 3.162

4.  Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast.

Authors:  E C LeRoy
Journal:  J Clin Invest       Date:  1974-10       Impact factor: 14.808

5.  A quantitative comparison of formation of spontaneous and virus-produced viable hybrids.

Authors:  H G Coon; M C Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1969-03       Impact factor: 11.205

6.  A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.

Authors:  R Ross; J Glomset; B Kariya; L Harker
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

7.  Platelets, thrombosis and atherosclerosis.

Authors:  J F Mustard; S Moore; M A Packham; R L Kinlough-Rathbone
Journal:  Prog Biochem Pharmacol       Date:  1977

8.  Evidence for cell-mediated immunity to collagen in progressive systemic sclerosis.

Authors:  J M Stuart; A E Postlethwaite; A H Kang
Journal:  J Lab Clin Med       Date:  1976-10

9.  Cutaneous antigen-stimulating lymphokine production by lymphocytes of patients with progressive systemic sclerosis (scleroderma).

Authors:  H Kondo; B S Rabin; G P Rodnan
Journal:  J Clin Invest       Date:  1976-12       Impact factor: 14.808

10.  Connective tissue synthesis by scleroderma skin fibroblasts in cell culture.

Authors:  E C Leroy
Journal:  J Exp Med       Date:  1972-06-01       Impact factor: 14.307
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  10 in total

1.  Response of scleroderma fibroblasts to various growth factors.

Authors:  K Takehara; Y Soma; A Igarashi; K Kikuchi; A Moro; Y Ishibashi
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

2.  Up regulated expression of tumour necrosis factor {alpha} converting enzyme in peripheral monocytes of patients with early systemic sclerosis.

Authors:  T Bohgaki; Y Amasaki; N Nishimura; M Bohgaki; Y Yamashita; M Nishio; K-I Sawada; S Jodo; T Atsumi; T Koike
Journal:  Ann Rheum Dis       Date:  2005-08       Impact factor: 19.103

Review 3.  Pathogenesis of scleroderma: the interrelationship of the immune and vascular hypotheses.

Authors:  E M Sternberg
Journal:  Surv Immunol Res       Date:  1985

Review 4.  Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?

Authors:  Terry J Smith
Journal:  Pharmacol Rev       Date:  2010-04-14       Impact factor: 25.468

Review 5.  Scarless wound healing: implications for the aesthetic surgeon.

Authors:  J Chang; J W Siebert; S A Schendel; B H Press; M T Longaker
Journal:  Aesthetic Plast Surg       Date:  1995 May-Jun       Impact factor: 2.326

6.  A fibroblast mitogen present in scleroderma but not control sera: inhibition by proteinase inhibitors.

Authors:  E C LeRoy; M B Kahaleh; S Mercurio
Journal:  Rheumatol Int       Date:  1983       Impact factor: 2.631

7.  Reduced response of scleroderma fibroblasts to fibroblast growth factor.

Authors:  K Nishioka; Y Kobayashi; I Katayama; S Sano
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

8.  Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis.

Authors:  M Kulozik; A Hogg; B Lankat-Buttgereit; T Krieg
Journal:  J Clin Invest       Date:  1990-09       Impact factor: 14.808

9.  Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta.

Authors:  L Rudnicka; J Varga; A M Christiano; R V Iozzo; S A Jimenez; J Uitto
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

Review 10.  Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities.

Authors:  Tomoaki Iwayama; Lorin E Olson
Journal:  Curr Rheumatol Rep       Date:  2013-02       Impact factor: 4.592
  10 in total

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