Literature DB >> 1697606

Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis.

M Kulozik1, A Hogg, B Lankat-Buttgereit, T Krieg.   

Abstract

The role of transforming growth factor beta 2 (TGF-beta 2) in the pathogenesis of systemic sclerosis (SSc) was investigated by in situ hybridization of skin biopsies from six patients with SSc. Two patients with acute systemic lupus erythematosis (SLE), one with acute dermatomyositis (DM), and three healthy individuals were used as controls. TGF-beta 2 mRNA was found to be co-localized with pro alpha 1(I) collagen expression around dermal blood vessels in all patients with the inflammatory stage of SSc, whereas there was no expression of either gene in the dermis of patients in the fibrotic stage, the SLE patients or the normal controls. These findings provide evidence that TGF-beta 2 released by inflammatory cells around blood vessels may play a role in mediating the collagen gene disregulation in fibrosis.

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Year:  1990        PMID： 1697606      PMCID： PMC296811          DOI： 10.1172/JCI114793

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  23 in total

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Journal:  Biochem J       Date:  1987-11-01       Impact factor: 3.857

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  35 in total

1.  Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.

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Review 4.  Cellular and molecular aspects of vascular dysfunction in systemic sclerosis.

Authors:  Maria Trojanowska
Journal:  Nat Rev Rheumatol       Date:  2010-06-29       Impact factor: 20.543

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8.  Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2.

Authors:  Izabela Chrobak; Stefania Lenna; Lukasz Stawski; Maria Trojanowska
Journal:  J Cell Physiol       Date:  2013-08       Impact factor: 6.384

9.  Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring.

Authors:  Julie T Daniels; Gregory S Schultz; Timothy D Blalock; Qian Garrett; Gary R Grotendorst; Nicholas M Dean; Peng T Khaw
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