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Literature DB >> 645830

Renal lesions induced induced by tilorone and an analog. Ultrastructure and acid phosphatase study.

Abstract

Tilorone, 2,7-bis-(diethylaminoethoxy)-fluoren-9-one hydrochloride, an interferon inducer, has been shown to cause hydropic degeneration in choroid plexus and distal convoluted tubules of kidney. Ultrastructural and histochemical studies of the renal lesion produced by tilorone and one of its analogs revealed striking accumulation of vacuoles and/or acid-phosphatase-positive lemellar bodies retricted to glomeruli, ascending limb of Henle's loop, and distal convoluted tubules.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1978 PMID： 645830 PMCID： PMC2018211

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

10 in total

1. ELECTRON MICROSCOPIC STUDIES OF THE EPITHELIUM OF THE PROXIMAL TUBULE OF THE RAT KIDNEY. I. THE INTRACELLULAR LOCALIZATION OF ACID PHOSPHATASE.

Authors: J L ERICSSON; B F TRUMP
Journal: Lab Invest Date: 1964-11 Impact factor: 5.662

2. Kidney changes in hypokalemic alkalosis in the rat.

Authors: B SPARGO
Journal: J Lab Clin Med Date: 1954-05

3. T-Lymphocyte depletion induced in rats by analogs of tilorone hydrochloride.

Authors: S Levine; R Sowinski; W L Albrecht
Journal: Toxicol Appl Pharmacol Date: 1977-04 Impact factor: 4.219

4. Decrease in the activity of the drug-metabolizing enzymes of rat liver following the administration of tilorone hydrochloride.

Authors: G A Leeson; S A Biedenbach; K Y Chan; J P Gibson; G J Wright
Journal: Drug Metab Dispos Date: 1976 May-Jun Impact factor: 3.922

5. Selective depletion of thymus dependent areas in lymphoid tissue by tilorone.

Authors: S Levine; J P Gibson; H Megel
Journal: Proc Soc Exp Biol Med Date: 1974-05

Review 6. Drug-induced phospholipidosis.

Authors: H Lüllmann; R Lüllmann-Rauch; O Wassermann
Journal: Ger Med Date: 1973

7. T-Lymphocyte depletion and lesions of choroid plexus and kidney induced by tertiary amines in rats.

Authors: S Levine; R Sowinski
Journal: Toxicol Appl Pharmacol Date: 1977-04 Impact factor: 4.219

8. Zonal changes in renal structure and phospholipid metabolism in potassium-deficient rats.

Authors: F G Toback; N G Ordónez; S L Bortz; B H Spargo
Journal: Lab Invest Date: 1976-02 Impact factor: 5.662

9. The anti-inflammatory actions of tilorone hydrochloride.

Authors: H Megel; A Raychaudhuri; I Shemano; T H Beaver; L L Thomas
Journal: Proc Soc Exp Biol Med Date: 1975-05

10. Some electron microscopical observations on liquid-crystalline phases in lipid-water systems.

Authors: W STOECKENIUS
Journal: J Cell Biol Date: 1962-02 Impact factor: 10.539

10 in total

6 in total

4. Histochemical evidence for lysosomal storage of acid glycosaminoglycans in splenic cells of rats treated with tilorone.

Authors: R Lüllmann-Rauch
Journal: Histochemistry Date: 1982

5. Lysosomal storage of sulfated glycosaminoglycans in renal interstitial cells of rats treated with tilorone.

Authors: R Lullmann-Rauch
Journal: Cell Tissue Res Date: 1987-12 Impact factor: 5.249

Review 6. Pulmonary and generalized lysosomal storage induced by amphiphilic drugs.

Authors: Z Hruban
Journal: Environ Health Perspect Date: 1984-04 Impact factor: 9.031