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Literature DB >> 223364

Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus.

Abstract

Several cationic amphiphilic drugs, each of which is known to induce generalized lipidosis in rats, were compared with respect to their cytological effects on rat choroid plexus epithelium. Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4'-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis. The ultrastructure of the chloroquine-induced vacuoles suggested storage of water-soluble materials (polar lipids and/or non-lipid materials) in addition to non-water-soluble polar lipids.

Entities: Chemical Disease Species

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Year: 1979 PMID： 223364 DOI： 10.1007/bf00690845

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

14 in total

Review 1. Lipidosis induced by amphiphilic cationic drugs.

Authors: H Lüllmann; R Lüllmann-Rauch; O Wassermann
Journal: Biochem Pharmacol Date: 1978 Impact factor: 5.858

2. Light-microscopic demonstration of drug-induced myelin bodies in the liver of rats.

Authors: G R Staiger
Journal: Experientia Date: 1974-04-15

3. Lipidosis-like alterations in spinal cord and cerebellar cortex of rats treated with chlorphentermine or tricylic antidepressants.

Authors: R Lüllmann-Rauch
Journal: Acta Neuropathol Date: 1974 Impact factor: 17.088

Review 4. The genetic mucopolysaccharidoses (GMS).

Authors: M D Haust
Journal: Int Rev Exp Pathol Date: 1973

5. Drug-induced generalized phospholipidosis.

Authors: T Shikata; T Kanetaka; Y Endo; K Nagashima
Journal: Acta Pathol Jpn Date: 1972-08

6. Studies on drug-induced lipidosis. 3. Lipid composition of the liver and some other tissues in clinical cases of "Niemann-Pick-like syndrome" induced by 4,4'-diethylaminoethoxyhexestrol.

Authors: A Yamamoto; S Adachi; K Ishikawa; T Yokomura; T Kitani
Journal: J Biochem Date: 1971-11 Impact factor: 3.387

Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus.

Review 1. Lipidosis induced by amphiphilic cationic drugs.

2. Light-microscopic demonstration of drug-induced myelin bodies in the liver of rats.

3. Lipidosis-like alterations in spinal cord and cerebellar cortex of rats treated with chlorphentermine or tricylic antidepressants.

Review 4. The genetic mucopolysaccharidoses (GMS).

5. Drug-induced generalized phospholipidosis.

6. Studies on drug-induced lipidosis. 3. Lipid composition of the liver and some other tissues in clinical cases of "Niemann-Pick-like syndrome" induced by 4,4'-diethylaminoethoxyhexestrol.

7. Differences in the retinotoxic action of chloroquine and phenothiazine derivatives.

8. Horseradish peroxidase uptake into the rat choroid plexus epithelium, with special reference to the lysosomal system.

9. Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants.

10. Renal lesions induced induced by tilorone and an analog. Ultrastructure and acid phosphatase study.

1. Morphological study of peripheral nerve changes induced by chloroquine treatment.

2. Disobutamide-induced cytoplasmic vacuoles in cultured dog coronary artery muscle cells.