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Literature DB >> 6452525

Maternal age and origin of non-disjunction in trisomy 21.

J F Mattei, S Ayme, M G Mattei, F Giraud.

Abstract

The role of maternal age in chromosomal non-disjunction was investigated by studying 51 families in whom the origin of the meiotic anomaly had been identified. Results of this study were compared with previously published data. This comparison did not show any difference in mean maternal age, nor in distribution of maternal ages when the origin of non-disjunction was maternal, or paternal, or occurred at the first or second meiotic division. These results make questionable the role of maternal age in the birth of Down's syndrome children.

Entities: Disease Species

Mesh：

Year: 1980 PMID： 6452525 PMCID： PMC1048600 DOI： 10.1136/jmg.17.5.368

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

26 in total

1. The fetal alcohol syndrome.

Authors: K L Jones; D W Smith
Journal: Teratology Date: 1975-08

2. A cytogenetic study of human spontaneous abortions using banding techniques.

Authors: M R Creasy; J A Crolla; E D Alberman
Journal: Hum Genet Date: 1976-02-29 Impact factor: 4.132

3. Origin of extra chromosome in trisomy 21.

Authors: G F Smith; S Sachdeva
Journal: Lancet Date: 1973-03-03 Impact factor: 79.321

4. Origin of extra chromosome in trisomy 21.

Authors: J A Robinson
Journal: Lancet Date: 1973-01-20 Impact factor: 79.321

5. A survey of 972 cytogenetically examined cases of Down's syndrome.

Authors: R J Gardner; A M Veale; M I Parslow; D M Becroft; R L Shaw; P H Fitzgerald; H E Hutchings; H R McCreanor; J Wong; J R Eiby; D A Howarth; S E Whyte
Journal: N Z Med J Date: 1973-11-14

6. Down's syndrome in Sweden. An epidemiological study of a three-year material.

Authors: A Lindsjö
Journal: Acta Paediatr Scand Date: 1974-07

7. Trisomy 21 in man due to maternal non-disjunction during the first meiotic division.

Authors: G Licznerski; J Lindsten
Journal: Hereditas Date: 1972 Impact factor: 3.271

8. Sex chromosome aneuploidy and parental age.

Authors: W M Brown; P Law; P G Smith
Journal: Ann Hum Genet Date: 1969-07 Impact factor: 1.670

9. On the distribution of phenotypes in XXY males and their parents.

Authors: J H Edwards
Journal: J Med Genet Date: 1971-12 Impact factor: 6.318

10. Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.

Authors: A P Craig-Holmes; F B Moore; M W Shaw
Journal: Am J Hum Genet Date: 1975-03 Impact factor: 11.025

11 in total

1. Parental age and the origin of trisomy 21. A study of 302 families.

Authors: F Dagna Bricarelli; M Pierluigi; M Landucci; A Arslanian; D A Coviello; M A Ferro; P Strigini
Journal: Hum Genet Date: 1989-04 Impact factor: 4.132

2. Distribution of meiotic recombination along nondisjunction chromosomes 21 in Down syndrome determined using cytogenetics and RFLP haplotyping.

Authors: H Meijer; G J Hamers; R J Jongbloed; G P Vaes-Peeters; R R van der Hulst; J P Geraedts
Journal: Hum Genet Date: 1989-10 Impact factor: 4.132

3. Trisomy 21 (Down syndrome): studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21.

Authors: G D Stewart; T J Hassold; A Berg; P Watkins; R Tanzi; D M Kurnit
Journal: Am J Hum Genet Date: 1988-02 Impact factor: 11.025

Maternal age and origin of non-disjunction in trisomy 21.

1. The fetal alcohol syndrome.

2. A cytogenetic study of human spontaneous abortions using banding techniques.

3. Origin of extra chromosome in trisomy 21.

4. Origin of extra chromosome in trisomy 21.

5. A survey of 972 cytogenetically examined cases of Down's syndrome.

6. Down's syndrome in Sweden. An epidemiological study of a three-year material.

7. Trisomy 21 in man due to maternal non-disjunction during the first meiotic division.

8. Sex chromosome aneuploidy and parental age.

9. On the distribution of phenotypes in XXY males and their parents.

10. Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.

1. Parental age and the origin of trisomy 21. A study of 302 families.

2. Distribution of meiotic recombination along nondisjunction chromosomes 21 in Down syndrome determined using cytogenetics and RFLP haplotyping.

3. Trisomy 21 (Down syndrome): studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21.

4. On the origin of chromosome anomaly.

5. Assessment of aneuploidy in the human female by using cytogenetics of IVF failures.

6. Down syndrome rates and relaxed selection at older maternal ages.

7. Trisomy 21: origin of non-disjunction.

8. A search for a paternal-age effect upon cases of 47, +21 in which the extra chromosome is of paternal origin.

Review 9. Molecular genetics of human chromosome 21.

10. Seasonality of pre-ovulatory non-disjunction and the aetiology of Down syndrome. A European collaborative study.